Knoevenagel reaction, 2-phenylpropanal, diethyl malonate, diethyl (R)-2-(2-phenylpropylidene)malonate, (8α,9S)-6′-Methoxy-2′-(1-methylethyl)cinchonan-9-amine, Quinine DerivativeFurther reactions, Knoevenagel Aza-Friedel-Crafts acylation, dibenzo[d,f][1,2]thiazepine 5,5-dioxide, 4-isopropoxynaphthalen-1-ol, (R)-7-(1-hydroxy-4-isopropoxynaphthalen-2-yl)-6,7-dihydrodibenzo[d,f][1,2]thiazepine 5,5-dioxide, Cinchonine BaseAza-Friedel-Crafts, Friedel-Crafts Michael cascade, N/C-substituted (Z)-2-ethylideneindolin-3-one, malononitrile, N/C-substituted (R)-2-amino-4-methyl-4,5-dihydropyrano[3,2-b]indole-3-carbonitrile, Cinchonine Base[4+2]-Cycloaddition, Cascade reaction, Cycloaddition, Michael Addition, Oxa-Michael Addition Spirocyclization, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, 2-methyl-3,5-dinitrobenzaldehyde, N/C-substituted tert-butyl (1’R,3R)-1′-hydroxy-5′,7′-dinitro-2-oxo-1′,4′-dihydro-2’H-spiro[indoline-3,3′-isoquinoline]-2′-carboxylate, Cinchonine BaseMannich, Mannich, Spirocyclization Aldol reaction, substituted benzaldehyde, cyclohexanone, (R)-2-((S)-hydroxy(phenyl)methyl)cyclohexan-1-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeAldol, Aldol alpha-Benzoyloxylation, 3,3-dimethylcyclohexan-1-one, benzoly peroxide, (S)-4,4-dimethyl-2-oxocyclohexyl benzoate, Trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAlpha-Benzoyloxylation, Further reactions Alkylation, methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate, 1-(bromomethyl)-4-nitrobenzene, methyl (S)-2-(4-nitrobenzyl)-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propen-1-yloxy)-cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation Fluorination, 4-nitrobenzyl 2-cyano-2-phenylacetate, (fluoromethylenedisulfonyl)dibenzene, 4-nitrobenzyl (R)-2-cyano-2-fluoro-2-phenylacetate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propynyloxy)-cinchonanium bromide, Cinchonine Derivativealpha-Fluorination, Fluorination Fluorination, methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (fluoromethylenedisulfonyl)dibenzene, methyl (R)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propynyloxy)-cinchonanium bromide, Cinchonine DerivativeFluorination, Fluorination of beta-ketoester Aldol reaction, 3-oxo-3-(phenylthio)propanoic acid, benzaldehyde, S-phenyl (R)-3-hydroxy-3-phenylpropanethioate, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-1-naphthalenesulfonamide, Quinine DerivativeAldol, Aldol« Older EntriesNext Entries »
Knoevenagel reaction, 2-phenylpropanal, diethyl malonate, diethyl (R)-2-(2-phenylpropylidene)malonate, (8α,9S)-6′-Methoxy-2′-(1-methylethyl)cinchonan-9-amine, Quinine DerivativeFurther reactions, Knoevenagel
Aza-Friedel-Crafts acylation, dibenzo[d,f][1,2]thiazepine 5,5-dioxide, 4-isopropoxynaphthalen-1-ol, (R)-7-(1-hydroxy-4-isopropoxynaphthalen-2-yl)-6,7-dihydrodibenzo[d,f][1,2]thiazepine 5,5-dioxide, Cinchonine BaseAza-Friedel-Crafts, Friedel-Crafts
Michael cascade, N/C-substituted (Z)-2-ethylideneindolin-3-one, malononitrile, N/C-substituted (R)-2-amino-4-methyl-4,5-dihydropyrano[3,2-b]indole-3-carbonitrile, Cinchonine Base[4+2]-Cycloaddition, Cascade reaction, Cycloaddition, Michael Addition, Oxa-Michael Addition
Spirocyclization, N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, 2-methyl-3,5-dinitrobenzaldehyde, N/C-substituted tert-butyl (1’R,3R)-1′-hydroxy-5′,7′-dinitro-2-oxo-1′,4′-dihydro-2’H-spiro[indoline-3,3′-isoquinoline]-2′-carboxylate, Cinchonine BaseMannich, Mannich, Spirocyclization
Aldol reaction, substituted benzaldehyde, cyclohexanone, (R)-2-((S)-hydroxy(phenyl)methyl)cyclohexan-1-one, (9R)-Cinchonan-9-amine, Cinchonine DerivativeAldol, Aldol
alpha-Benzoyloxylation, 3,3-dimethylcyclohexan-1-one, benzoly peroxide, (S)-4,4-dimethyl-2-oxocyclohexyl benzoate, Trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAlpha-Benzoyloxylation, Further reactions
Alkylation, methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate, 1-(bromomethyl)-4-nitrobenzene, methyl (S)-2-(4-nitrobenzyl)-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propen-1-yloxy)-cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation
Fluorination, 4-nitrobenzyl 2-cyano-2-phenylacetate, (fluoromethylenedisulfonyl)dibenzene, 4-nitrobenzyl (R)-2-cyano-2-fluoro-2-phenylacetate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propynyloxy)-cinchonanium bromide, Cinchonine Derivativealpha-Fluorination, Fluorination
Fluorination, methyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (fluoromethylenedisulfonyl)dibenzene, methyl (R)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-[[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]methyl]-9-(2-propynyloxy)-cinchonanium bromide, Cinchonine DerivativeFluorination, Fluorination of beta-ketoester
Aldol reaction, 3-oxo-3-(phenylthio)propanoic acid, benzaldehyde, S-phenyl (R)-3-hydroxy-3-phenylpropanethioate, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-1-naphthalenesulfonamide, Quinine DerivativeAldol, Aldol
