Cascade reaction, (E)-1-methyl-4-(2-nitrovinyl)benzene, ethyl (E)-6-nitrohex-2-enoate, ethyl 2-((1S,2R,3R,4S)-2,4-dinitro-3-(p-tolyl)cyclohexyl)acetate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Cyclization [3+2] Cycloaddition, alpha-substituted isocyanoacetates, N-aryl maleimides, 1,5-substituted (1S,3aS,6aR)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine Derivative[3+2]-Cycloaddition, Cycloaddition Michael Addition, methyl (10aR,Z)-3-oxo-1,2,3,5,6,7,8,10a-octahydropyrrolo[1,2-a]azocine-2-carboxylate, 2-allyl-4-(2-nitroethyl)furan, methyl (2S,10aR,Z)-2-((S)-1-(5-allylfuran-3-yl)-2-nitroethyl)-3-oxo-1,2,3,5,6,7,8,10a-octahydropyrrolo[1,2-a]azocine-2-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition Alkylation, 2-benzyl-2-methylcyclopent-4-ene-1,3-dione, nitromethane, (R)-2-benzyl-2,4-dimethylcyclopent-4-ene-1,3-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeAlkylation, Alkylation Fluorodesilylation, organosilanes, alpha,beta unsaturated ketones, substituted (R,E)-5-(ethylideneamino)heptan-2-one, Amberlyst A 26, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium fluoride, Cinchonine DerivativeAlkylation, alpha-Alkylation Umpolung, substituted tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, 3,4-disubstituted-2-((4-nitrophenyl)sulfonyl)-1,2-oxazetidine, substituted tert-butyl (2S)-2-(1,2-disubstituted-2-((4-nitrophenyl)sulfonamido)ethoxy)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-[[4,4′′-bis(1,1-dimethylethyl)[1,1′:4′,1′′-terphenyl]-2′-yl]methyl]-9-(2,2-dimethyl-1-oxopropoxy)-cinchonanium bromide, Cinchonine DerivativeFurther reactions, Umpolung Amination, 3-phenylbutan-2-one, di-tert-butyl (E)-diazene-1,2-dicarboxylate, di-tert-butyl (S)-1-(3-oxo-2-phenylbutan-2-yl)hydrazine-1,2-dicarboxylate, trifluoroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination Michael Addition, methyl 2-fluoro-3-((4-methoxyphenyl)thio)-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, methyl (2R,3R)-2-fluoro-2-(((4-methoxyphenyl)thio)carbonyl)-4-nitro-3-phenylbutanoate, N-[3,5-bis(trifluoromethyl)phenyl]- N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition Trifluoromethylsilylation, (chloromethyl)dimethyl(trifluoromethyl)silane, substituted 1-phenylbutan-1-one, substituted (4S,6R)-4-substituted-2,2,dimethyl-6-phenyl-6-(trifluoromethyl)-1,2-oxasilinane, (9S)-(9′′S)-1,1′′-[1,3-phenylenebis(methylene)]bis[9-hydroxy-cinchonanium bromide (1:2), Cinchonine DerivativeCyclization, Cyclization, Fluorination, Fluoromethylation, Further Cyclizations, Trifluoromethylation Michael Addition, nitro esters, α,β-unsatureted ketones, substituted 2-nitro-5-oxo-5-substituted-pentanoate, (9R)-Cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Cascade reaction, (E)-1-methyl-4-(2-nitrovinyl)benzene, ethyl (E)-6-nitrohex-2-enoate, ethyl 2-((1S,2R,3R,4S)-2,4-dinitro-3-(p-tolyl)cyclohexyl)acetate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Cyclization
[3+2] Cycloaddition, alpha-substituted isocyanoacetates, N-aryl maleimides, 1,5-substituted (1S,3aS,6aR)-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine Derivative[3+2]-Cycloaddition, Cycloaddition
Michael Addition, methyl (10aR,Z)-3-oxo-1,2,3,5,6,7,8,10a-octahydropyrrolo[1,2-a]azocine-2-carboxylate, 2-allyl-4-(2-nitroethyl)furan, methyl (2S,10aR,Z)-2-((S)-1-(5-allylfuran-3-yl)-2-nitroethyl)-3-oxo-1,2,3,5,6,7,8,10a-octahydropyrrolo[1,2-a]azocine-2-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
Alkylation, 2-benzyl-2-methylcyclopent-4-ene-1,3-dione, nitromethane, (R)-2-benzyl-2,4-dimethylcyclopent-4-ene-1,3-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea, Dihydroquinine DerivativeAlkylation, Alkylation
Fluorodesilylation, organosilanes, alpha,beta unsaturated ketones, substituted (R,E)-5-(ethylideneamino)heptan-2-one, Amberlyst A 26, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[2′-(1,1-dimethylethoxy)[1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-cinchonanium fluoride, Cinchonine DerivativeAlkylation, alpha-Alkylation
Umpolung, substituted tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, 3,4-disubstituted-2-((4-nitrophenyl)sulfonyl)-1,2-oxazetidine, substituted tert-butyl (2S)-2-(1,2-disubstituted-2-((4-nitrophenyl)sulfonamido)ethoxy)-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-1-[[4,4′′-bis(1,1-dimethylethyl)[1,1′:4′,1′′-terphenyl]-2′-yl]methyl]-9-(2,2-dimethyl-1-oxopropoxy)-cinchonanium bromide, Cinchonine DerivativeFurther reactions, Umpolung
Amination, 3-phenylbutan-2-one, di-tert-butyl (E)-diazene-1,2-dicarboxylate, di-tert-butyl (S)-1-(3-oxo-2-phenylbutan-2-yl)hydrazine-1,2-dicarboxylate, trifluoroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination
Michael Addition, methyl 2-fluoro-3-((4-methoxyphenyl)thio)-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, methyl (2R,3R)-2-fluoro-2-(((4-methoxyphenyl)thio)carbonyl)-4-nitro-3-phenylbutanoate, N-[3,5-bis(trifluoromethyl)phenyl]- N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
Trifluoromethylsilylation, (chloromethyl)dimethyl(trifluoromethyl)silane, substituted 1-phenylbutan-1-one, substituted (4S,6R)-4-substituted-2,2,dimethyl-6-phenyl-6-(trifluoromethyl)-1,2-oxasilinane, (9S)-(9′′S)-1,1′′-[1,3-phenylenebis(methylene)]bis[9-hydroxy-cinchonanium bromide (1:2), Cinchonine DerivativeCyclization, Cyclization, Fluorination, Fluoromethylation, Further Cyclizations, Trifluoromethylation
Michael Addition, nitro esters, α,β-unsatureted ketones, substituted 2-nitro-5-oxo-5-substituted-pentanoate, (9R)-Cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition
