Aldol reaction, α-azido ketones, ethyl pyruvate, substituted ethyl 3-azido-2-hydroxy-2-methyl-4-oxo-4-phenylbutanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea, Quinine DerivativeAldol, Aldol Umpolung, imines, α,β-unsaturated ketones, γ-amino ketones, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[4-(1,1-dimethylethoxy)-3,5-di-2-naphthalenylphenyl]methyl]-cinchonanium bromide, Cinchonine DerivativeFurther reactions, Isomerization, Umpolung Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (9R)-N-[[2-(diphenylphosphino)phenyl]methyl]-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeHydrogenation, Hydrogenation of beta-ketoesters Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (S)-N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methoxyquinolin-4-yl)-1-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine, Quinine DerivativeHydrogenation, Hydrogenation of beta-ketoesters Michael Addition, vinylsulfones, diethyl (nitromethyl)phosphonates, (R)-substituted diethyl (1-nitro-3-(arylsulfonyl)propyl)phosphonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Cascade reaction, α,β-unsaturated-β-hydroxyketones, nitroalkenes, substituted dihydropyrane, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Spirocyclization, 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one, substituted 2-(2-oxoindolin-3-ylidene)acetonitrile, spirocyclic compounds, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization α-benzoyloxylation, aldehydes, benzoyl peroxide, (2S)-substituted 1-oxopropan-2-yl benzoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Hydroxymethylation, Further reactions Mannich reaction, isatin derived ketimines, acetylacetone, substituted (S)-(3-(2,4-dioxopentan-3-yl)-2-oxoindolin-3-yl)carbamate, 3-[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-2-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Michael Addition, α-nitrophosphonates, aryl acrylates, α-substituted α-nitrophosphonates, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Aldol reaction, α-azido ketones, ethyl pyruvate, substituted ethyl 3-azido-2-hydroxy-2-methyl-4-oxo-4-phenylbutanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]urea, Quinine DerivativeAldol, Aldol
Umpolung, imines, α,β-unsaturated ketones, γ-amino ketones, (9S)-9-[(6-chloro-2,5-diphenyl-4-pyrimidinyl)oxy]-1-[[4-(1,1-dimethylethoxy)-3,5-di-2-naphthalenylphenyl]methyl]-cinchonanium bromide, Cinchonine DerivativeFurther reactions, Isomerization, Umpolung
Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (9R)-N-[[2-(diphenylphosphino)phenyl]methyl]-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeHydrogenation, Hydrogenation of beta-ketoesters
Hydrogenation, β-keto esters, hydrogen, 3-substituted methyl 3-hydroxypropanoate, Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium, (S)-N-(2-(diphenylphosphaneyl)benzyl)-1-(6-methoxyquinolin-4-yl)-1-((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine, Quinine DerivativeHydrogenation, Hydrogenation of beta-ketoesters
Michael Addition, vinylsulfones, diethyl (nitromethyl)phosphonates, (R)-substituted diethyl (1-nitro-3-(arylsulfonyl)propyl)phosphonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Cascade reaction, α,β-unsaturated-β-hydroxyketones, nitroalkenes, substituted dihydropyrane, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Spirocyclization, 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one, substituted 2-(2-oxoindolin-3-ylidene)acetonitrile, spirocyclic compounds, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization
α-benzoyloxylation, aldehydes, benzoyl peroxide, (2S)-substituted 1-oxopropan-2-yl benzoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Hydroxymethylation, Further reactions
Mannich reaction, isatin derived ketimines, acetylacetone, substituted (S)-(3-(2,4-dioxopentan-3-yl)-2-oxoindolin-3-yl)carbamate, 3-[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]-4-(tricyclo[3.3.1.13,7]dec-2-ylamino)-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Michael Addition, α-nitrophosphonates, aryl acrylates, α-substituted α-nitrophosphonates, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
