Decarboxylative Mannich reaction, tert-butyl (Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)carbamate, 3-(4-fluorophenyl)-3-oxopropanoic acid, tert-butyl (S)-(4-(2-(4-fluorophenyl)-2-oxoethyl)-3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)carbamate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Nitro-Mannich, N-phosphoryl imines, alpha-substituted nitroacetates, 2,3-disubstituted methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-2-nitro-propanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(9S)-cinchonan-9-ylthiourea, Cinchonine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Vinylogous mannich reaction, tert-butyl (Z)-(1-benzyl-2-oxoindolin-3-ylidene)carbamate, 2-(1-(3-chlorophenyl)ethylidene)malononitrile, tert-butyl (S)-(1-benzyl-3-(2-(3-chlorophenyl)-3,3-dicyanoallyl)-2-oxoindolin-3-yl)carbamate, 3-[(1,1-Dimethylethyl)amino]-4-[[(8α,9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Cyclopropanation, 1-Chloro-10-phenyl-6-decene-2,8-dione, (1S,6R,7S)-7-(3-phenylpropanoyl)bicyclo[4.1.0]heptan-2-one, (8α,9R)-6′,9-Dimethoxy-2′-methylcinchonan, Quinine DerivativeCyclopropanation Spirocyclization, substituted 2-methylene-1,3-Indandione, alpha,beta-unsaturated ketones, indanedione-fused 2,6-disubstituted trans-spirocyclohexanones, (9R)-Cinchonan-9-amine, Cinchonine DerivativeCycloaddition, Diels-Alder reaction, Michael, Michael Addition, Spirocyclization Michael Addition, (R,E)-3-(5-methylhex-2-enoyl)-4-phenyloxazolidin-2-one, (R)-3-((S)-5-methyl-3-(nitromethyl)hexanoyl)-4-phenyloxazolidin-2-one, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeMichael, Michael Addition Michael Addition, cyclohex-2-en-1-one, (R)-[1,1′-bi(cyclohexan)]-6-ene-2,3′-dione, (9S)-9-hydroxy-1-[[3,4,5-tris(phenylmethoxy)phenyl]methyl]-cinchonanium bromide, Cinchonine DerivativeMichael, Michael Addition Cyclization, 2-(1H-pyrrol-2-yl)aniline, aldehydes or 1,1,1-trifluoroketones, 5substituted 1,2,3,5,6,10b-hexahydropyrrolo[1,2-c]quinazoline, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeCyclization, Cyclization, Further Cyclizations Spirocyclization, N/C-substituted 2-(2-oxoindolin-3-ylidene)malononitrile, cyclopent-2-en-1-one, N/C-substituted (S)-2-(2-oxo-3-(5-oxocyclopent-1-en-1-yl)indolin-3-yl)malononitrile, 2-mercaptobenzoic acid, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium bromide, Cinchonine DerivativeSpirocyclization Bromolactonization, alpha,beta-unsaturated ketones, N-bromosuccinimide, (3S)-substituted 3,4-dihydroisocumarin, N-(9R)-cinchonan-9-yl-N′-(4-methoxy-2,3-dimethylphenyl)-urea, Cinchonine DerivativeBromination, Cyclization, Lactonization« Older EntriesNext Entries »
Decarboxylative Mannich reaction, tert-butyl (Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)carbamate, 3-(4-fluorophenyl)-3-oxopropanoic acid, tert-butyl (S)-(4-(2-(4-fluorophenyl)-2-oxoethyl)-3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)carbamate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Nitro-Mannich, N-phosphoryl imines, alpha-substituted nitroacetates, 2,3-disubstituted methyl (2S,3S)-3-((diethoxyphosphoryl)amino)-2-nitro-propanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(9S)-cinchonan-9-ylthiourea, Cinchonine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Vinylogous mannich reaction, tert-butyl (Z)-(1-benzyl-2-oxoindolin-3-ylidene)carbamate, 2-(1-(3-chlorophenyl)ethylidene)malononitrile, tert-butyl (S)-(1-benzyl-3-(2-(3-chlorophenyl)-3,3-dicyanoallyl)-2-oxoindolin-3-yl)carbamate, 3-[(1,1-Dimethylethyl)amino]-4-[[(8α,9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Cyclopropanation, 1-Chloro-10-phenyl-6-decene-2,8-dione, (1S,6R,7S)-7-(3-phenylpropanoyl)bicyclo[4.1.0]heptan-2-one, (8α,9R)-6′,9-Dimethoxy-2′-methylcinchonan, Quinine DerivativeCyclopropanation
Spirocyclization, substituted 2-methylene-1,3-Indandione, alpha,beta-unsaturated ketones, indanedione-fused 2,6-disubstituted trans-spirocyclohexanones, (9R)-Cinchonan-9-amine, Cinchonine DerivativeCycloaddition, Diels-Alder reaction, Michael, Michael Addition, Spirocyclization
Michael Addition, (R,E)-3-(5-methylhex-2-enoyl)-4-phenyloxazolidin-2-one, (R)-3-((S)-5-methyl-3-(nitromethyl)hexanoyl)-4-phenyloxazolidin-2-one, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, cyclohex-2-en-1-one, (R)-[1,1′-bi(cyclohexan)]-6-ene-2,3′-dione, (9S)-9-hydroxy-1-[[3,4,5-tris(phenylmethoxy)phenyl]methyl]-cinchonanium bromide, Cinchonine DerivativeMichael, Michael Addition
Cyclization, 2-(1H-pyrrol-2-yl)aniline, aldehydes or 1,1,1-trifluoroketones, 5substituted 1,2,3,5,6,10b-hexahydropyrrolo[1,2-c]quinazoline, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium chloride, Cinchonine DerivativeCyclization, Cyclization, Further Cyclizations
Spirocyclization, N/C-substituted 2-(2-oxoindolin-3-ylidene)malononitrile, cyclopent-2-en-1-one, N/C-substituted (S)-2-(2-oxo-3-(5-oxocyclopent-1-en-1-yl)indolin-3-yl)malononitrile, 2-mercaptobenzoic acid, (9S)-9-hydroxy-1-(phenylmethyl)-cinchonanium bromide, Cinchonine DerivativeSpirocyclization
Bromolactonization, alpha,beta-unsaturated ketones, N-bromosuccinimide, (3S)-substituted 3,4-dihydroisocumarin, N-(9R)-cinchonan-9-yl-N′-(4-methoxy-2,3-dimethylphenyl)-urea, Cinchonine DerivativeBromination, Cyclization, Lactonization
