Fluorination, beta-ketoesters, selectfluor, 1-substituted pyrrole-2,5-dione, substituted ethyl (S)-2-((S)-2,5-dioxopyrrolidin-3-yl)-2-fluoro-3-oxobutanoate, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Quinidine Derivativealpha-Fluorination, Desymmetrization, Fluorination, Michael, Michael Addition Spirocyclization, 2-oxocyclohexane-1-carbaldehyde, aliphatic beta,gamma-unsaturated α-keto esters, substituted (6R)-1,7-dioxo-2-oxaspiro[5.5]undecane-3-carboxylate, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl) ((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization Spirocyclization, alpha‐cyano ketones, isatylidene malononitriles, Spiro [4H‐pyran‐oxindoles], N-[(1S,2S)-2-[[[[(9R)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-methanesulfonamide, Quinidine DerivativeMichael, Michael Addition, Spirocyclization Spirocyclization, 3-isothiocyanato oxindoles, 3-trifluoroethylidene oxindoles, 3′-trifluoromethyl substituted 3, 2′-pyrrolidinyl-bispirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization Spirocyclization, substituted 3-(hydroxymethylene)benzofuran-2(3H)-one, alpha,beta-unsaturated methylketones, spirocyclic benzofuranones, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeAldol, Aldol, Michael, Michael Addition, Spirocyclization Spirocyclization, 2-arylideneindane-1,3-diones, nitro aldehydes, spiro-1,3-indandiones with three stereocenters, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAldol, Aldol, Michael, Michael Addition, Spirocyclization Cyclization, substituted 2-(2-oxoethyl)malononitrile, (E)-1-nitroalk-1-enes, 2,4-disubstituted (1S,2R)-1-cyano-3-nitrocyclopent-3-ene-1-carboxamide, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dithione, Quinidine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael, Michael Addition Cyclization, substituted 2-nitro-5-oxopentanoate, (E)-1-nitroalk-1-enes, densely functionalised cyclohexanes, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl) ((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael, Michael Addition Mannich reaction, substitutedtert-butyl (tosylmethyl)carbamate, substituted tert-butyl ethylidenecarbamate, beta-phenyl sulfonyl acetonitrile, substituted tert-butyl (2-cyanoethyl)carbamate, (9S)-9-hydroxy-6′-methoxy-1-[(2-nitrophenyl)methyl]-cinchonanium chloride, Quinidine DerivativeMannich, Mannich Oxa-Michael Addition, substituted (E)-2-oxopent-3-enoate, 7-substituted (E)-7-oxo-hept-5-enal, cis‐and trans‐fused pyrano [2,3‐b] pyrans, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeCycloaddition, Diels-Alder reaction, Michael Addition, Oxa-Michael Addition« Older EntriesNext Entries »
Fluorination, beta-ketoesters, selectfluor, 1-substituted pyrrole-2,5-dione, substituted ethyl (S)-2-((S)-2,5-dioxopyrrolidin-3-yl)-2-fluoro-3-oxobutanoate, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Quinidine Derivativealpha-Fluorination, Desymmetrization, Fluorination, Michael, Michael Addition
Spirocyclization, 2-oxocyclohexane-1-carbaldehyde, aliphatic beta,gamma-unsaturated α-keto esters, substituted (6R)-1,7-dioxo-2-oxaspiro[5.5]undecane-3-carboxylate, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl) ((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
Spirocyclization, alpha‐cyano ketones, isatylidene malononitriles, Spiro [4H‐pyran‐oxindoles], N-[(1S,2S)-2-[[[[(9R)-6′-methoxycinchonan-9-yl]amino]thioxomethyl]amino]-1,2-diphenylethyl]-methanesulfonamide, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
Spirocyclization, 3-isothiocyanato oxindoles, 3-trifluoroethylidene oxindoles, 3′-trifluoromethyl substituted 3, 2′-pyrrolidinyl-bispirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeMichael, Michael Addition, Spirocyclization
Spirocyclization, substituted 3-(hydroxymethylene)benzofuran-2(3H)-one, alpha,beta-unsaturated methylketones, spirocyclic benzofuranones, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeAldol, Aldol, Michael, Michael Addition, Spirocyclization
Spirocyclization, 2-arylideneindane-1,3-diones, nitro aldehydes, spiro-1,3-indandiones with three stereocenters, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAldol, Aldol, Michael, Michael Addition, Spirocyclization
Cyclization, substituted 2-(2-oxoethyl)malononitrile, (E)-1-nitroalk-1-enes, 2,4-disubstituted (1S,2R)-1-cyano-3-nitrocyclopent-3-ene-1-carboxamide, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[(phenylmethyl)amino]-3-cyclobutene-1,2-dithione, Quinidine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael, Michael Addition
Cyclization, substituted 2-nitro-5-oxopentanoate, (E)-1-nitroalk-1-enes, densely functionalised cyclohexanes, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl) ((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael, Michael Addition
Mannich reaction, substitutedtert-butyl (tosylmethyl)carbamate, substituted tert-butyl ethylidenecarbamate, beta-phenyl sulfonyl acetonitrile, substituted tert-butyl (2-cyanoethyl)carbamate, (9S)-9-hydroxy-6′-methoxy-1-[(2-nitrophenyl)methyl]-cinchonanium chloride, Quinidine DerivativeMannich, Mannich
Oxa-Michael Addition, substituted (E)-2-oxopent-3-enoate, 7-substituted (E)-7-oxo-hept-5-enal, cis‐and trans‐fused pyrano [2,3‐b] pyrans, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]thiourea, Quinidine DerivativeCycloaddition, Diels-Alder reaction, Michael Addition, Oxa-Michael Addition
