Oxa-Michael, (E)-4,4,4-trifluoro-1,3-diphenylbut-2-en-1-one, hydroxylamine, trifluoromethyl‐substituted 2‐isoxazolines, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition Synthesis of N-N axially coumpounds, N-(4-oxo-2-substituted-quinazolin-3(4H)-yl)substituted-amide, substituted Methylbromide, N-substituted-N-(2-substituted-4-oxoquinazolin-3(4H)-yl)substituted-amide, 1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-9-[[[[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino]carbonyl]amino]-Cinchoanium bromide, Cinchonidine DerivativeSynthesis of N-N axially compounds Michael Addition, β‐silylmethylene malonate, 2-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, diethyl (R)-2-((5-acetoxy-1-(4-bromophenyl)-3-methyl-1H-pyrazol-4-yl)(1,1,3,3,3-pentamethyldisiloxaneyl)methyl)malonate, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMichael, Michael Addition Michael Addition, beta‐silylmethylene malonates, nitromethane, diethyl (R)-2-(1-(dimethyl(phenyl)silyl)-2-nitroethyl)malonate, N-[(9R)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-Thiourea, Quinidine DerivativeMichael, Michael Addition Bromocyclization, olefinic dicarbonyl compounds, N-bromsuccinimid, (S)-(5-(bromomethyl)-5-substituted-2-phenyl-4,5-dihydrofuran-3-yl)(phenyl)methanone, (9S)-6′-methoxy-9-[N-(2,4,6-trimethoxyphenyl)carbamothioate]-cinchonan-9-ol, Quinidine DerivativeBromination, Cyclization, Cyclization, Further Cyclizations Atropisomer synthesis, O/C-substituted 2′-hydroxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, atropisomeric biaryls, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAlkylation, Alkylation, Atropisomer synthesis Bromination, 8‐Arylquinolines, N-bromoacetamide, 2,4,6-tribromo-3-(isoquinolin-1-yl)phenol, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]-urea, Quinidine DerivativeAtropisomer synthesis, Bromination alpha-Alkylation, cyclic ketones, 1-(bromomethyl)-2,4-dinitrobenzene, (2S,4S)-2-(2,4-dinitrobenzyl)-4-methylcyclohexan-1-one, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeAlkylation, Alkylation, Desymmetrization O-Alkylation, C/O-substituted 2′-hydroxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, atropisomeric biaryls, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAlkylation, Alkylation Oxa-Michael, (E)-5-(4-hydroxyphenyl)-1-(p-tolyl)pent-2-en-1-one, Iodobenzene diacetate, (S)-2-(2-oxo-2-(p-tolyl)ethyl)-1-oxaspiro[4.5]deca-6,9-dien-8-one, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[[(1R)-1-phenylethyl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Michael Addition, Oxa-Michael Addition, Spirocyclization« Older EntriesNext Entries »
Oxa-Michael, (E)-4,4,4-trifluoro-1,3-diphenylbut-2-en-1-one, hydroxylamine, trifluoromethyl‐substituted 2‐isoxazolines, 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition
Synthesis of N-N axially coumpounds, N-(4-oxo-2-substituted-quinazolin-3(4H)-yl)substituted-amide, substituted Methylbromide, N-substituted-N-(2-substituted-4-oxoquinazolin-3(4H)-yl)substituted-amide, 1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-9-[[[[(1R,2S)-2-hydroxy-1,2-diphenylethyl]amino]carbonyl]amino]-Cinchoanium bromide, Cinchonidine DerivativeSynthesis of N-N axially compounds
Michael Addition, β‐silylmethylene malonate, 2-(4-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, diethyl (R)-2-((5-acetoxy-1-(4-bromophenyl)-3-methyl-1H-pyrazol-4-yl)(1,1,3,3,3-pentamethyldisiloxaneyl)methyl)malonate, 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMichael, Michael Addition
Michael Addition, beta‐silylmethylene malonates, nitromethane, diethyl (R)-2-(1-(dimethyl(phenyl)silyl)-2-nitroethyl)malonate, N-[(9R)-6′-methoxycinchonan-9-yl]-N′-(4-nitrophenyl)-Thiourea, Quinidine DerivativeMichael, Michael Addition
Bromocyclization, olefinic dicarbonyl compounds, N-bromsuccinimid, (S)-(5-(bromomethyl)-5-substituted-2-phenyl-4,5-dihydrofuran-3-yl)(phenyl)methanone, (9S)-6′-methoxy-9-[N-(2,4,6-trimethoxyphenyl)carbamothioate]-cinchonan-9-ol, Quinidine DerivativeBromination, Cyclization, Cyclization, Further Cyclizations
Atropisomer synthesis, O/C-substituted 2′-hydroxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, atropisomeric biaryls, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAlkylation, Alkylation, Atropisomer synthesis
Bromination, 8‐Arylquinolines, N-bromoacetamide, 2,4,6-tribromo-3-(isoquinolin-1-yl)phenol, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxycinchonan-9-yl]-urea, Quinidine DerivativeAtropisomer synthesis, Bromination
alpha-Alkylation, cyclic ketones, 1-(bromomethyl)-2,4-dinitrobenzene, (2S,4S)-2-(2,4-dinitrobenzyl)-4-methylcyclohexan-1-one, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeAlkylation, Alkylation, Desymmetrization
O-Alkylation, C/O-substituted 2′-hydroxy-3,4-dihydro-[1,1′-binaphthalen]-2(1H)-one, benzyl iodide, atropisomeric biaryls, (9S)-9-hydroxy-6′-methoxy-1-[(2,3,4-trifluorophenyl)methyl]-cinchonanium bromide, Quinidine DerivativeAlkylation, Alkylation
Oxa-Michael, (E)-5-(4-hydroxyphenyl)-1-(p-tolyl)pent-2-en-1-one, Iodobenzene diacetate, (S)-2-(2-oxo-2-(p-tolyl)ethyl)-1-oxaspiro[4.5]deca-6,9-dien-8-one, 3-[[(9R)-6′-methoxycinchonan-9-yl]amino]-4-[[(1R)-1-phenylethyl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization, Michael Addition, Oxa-Michael Addition, Spirocyclization
