Diels Alder reaction, N,N’-((1E,2E)-4-benzoylcyclohexa-3,5-diene-1,2-diylidene)dibenzamide, 3-(methylthio)propanoyl chloride, (S)-(3-((methylthio)methyl)-2-oxo-2,3-dihydroquinoxaline-1,4,6-triyl)tris(phenylmethanone), 6′-methoxy-(9S)-Cinchonan-9-ol-9-benzoate, Quinidine DerivativeCycloaddition, Diels-Alder reaction Michael Addition, (E)-3-methyl-5-(4-methylpent-1-en-1-yl)-4-nitroisoxazole, nitromethane, (S)-3-methyl-5-(4-methyl-2-(nitromethyl)pentyl)-4-nitroisoxazole, (9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeMichael, Michael Addition Fluorination, substituted tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, N-fluorbenzolsulfonimid, substituted tert-butyl (S)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (1S,2R,4S,5R)-2-((S)-((2-((3,5-bis(trifluoromethyl)phenyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)(6-methoxyquinolin-4-yl)methyl)-1-(3,5-di-tert-butylbenzyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeFluorination, Fluorination of beta-ketoester Fluorination, substituted 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, substituted 2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-9-fluoro-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinidine DerivativeFluorination, Fluorination of beta-ketoester Mannich reaction, tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates, S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate), 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMannich, Mannich Spirocyclization, 4-alkylideneisoxazol-5-ones, methyl vinyl ketones, 6,10-disubstituted (6S,10S)-4-methyl-2-oxa-3-azaspiro[4.5]dec-3-ene-1,8-dione, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeSpirocyclization Allylic Alkylation, (E)-1,3-diphenylallyl acetate, dimethyl malonate, dimethyl (R,E)-2-(1,3-diphenylallyl)malonate, Di-μ-chlorobis(η3-2-propenyl)dipalladium, (8α,9R)-9-[[(4S,5S)-4,5-Diphenyl-1,3,2-dioxaphospholan-2-yl]oxy]cinchonan, Cinchonidine DerivativeAlkylation, Allylic Alkylation Oxysulfonylation, β,γ-unsaturated ketoximes, sulfonyl chlorides, sulfonyl-containing isoxazolines, cupric acetate, N-(8α,9S)-Cinchonan-9-yl-2,3,5,6-tetramethylbenzenesulfonamide, Cinchonidine DerivativeCyclization, Further reactions, Isoxazoline cyclization, Oxysulfonylation, Sulfonylation Oxa-Michael, 2,4-disubstituted tert-butyl (Z)-4-oxobut-2-enoate, hydroxylamine, carboxy-substituted 2-isoxazolines, (1S,2R,4S,5R)-1-(2,5-bis(trifluoromethyl)benzyl)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition Intramolecular Hydroarylation, 1-((2-(1-methyl-1H-indol-2-yl)phenyl)ethynyl)naphthalen-2-ol, 1-(11-methyl-11H-benzo[a]carbazol-6-yl)naphthalen-2-ol, Cinchonidine BaseCyclization, Further Cyclizations, Intramolecular cyclization« Older EntriesNext Entries »
Diels Alder reaction, N,N’-((1E,2E)-4-benzoylcyclohexa-3,5-diene-1,2-diylidene)dibenzamide, 3-(methylthio)propanoyl chloride, (S)-(3-((methylthio)methyl)-2-oxo-2,3-dihydroquinoxaline-1,4,6-triyl)tris(phenylmethanone), 6′-methoxy-(9S)-Cinchonan-9-ol-9-benzoate, Quinidine DerivativeCycloaddition, Diels-Alder reaction
Michael Addition, (E)-3-methyl-5-(4-methylpent-1-en-1-yl)-4-nitroisoxazole, nitromethane, (S)-3-methyl-5-(4-methyl-2-(nitromethyl)pentyl)-4-nitroisoxazole, (9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-hydroxy-6′-methoxy-cinchonanium bromide, Quinidine DerivativeMichael, Michael Addition
Fluorination, substituted tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, N-fluorbenzolsulfonimid, substituted tert-butyl (S)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (1S,2R,4S,5R)-2-((S)-((2-((3,5-bis(trifluoromethyl)phenyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)(6-methoxyquinolin-4-yl)methyl)-1-(3,5-di-tert-butylbenzyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeFluorination, Fluorination of beta-ketoester
Fluorination, substituted 1-oxo-2,3-dihydro-1H-indene-2-carboxylate, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, substituted 2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylate, (9S)-9-fluoro-6′-methoxy-1-(phenylmethyl)-cinchonanium chloride, Quinidine DerivativeFluorination, Fluorination of beta-ketoester
Mannich reaction, tert-butyl (1-(phenylsulfonyl)-2-(2,4,5-trifluorophenyl)ethyl)carbamate, dithiomalonates, S,S-dibenzyl (R)-2-(1-((tert-butoxycarbonyl)amino)-2-(2,4,5-trifluorophenyl)ethyl)propanebis(thioate), 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((R)-(6-methoxyquinolin-4-yl)((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione, Quinidine DerivativeMannich, Mannich
Spirocyclization, 4-alkylideneisoxazol-5-ones, methyl vinyl ketones, 6,10-disubstituted (6S,10S)-4-methyl-2-oxa-3-azaspiro[4.5]dec-3-ene-1,8-dione, (9R)-6′-methoxy-cinchonan-9-amine, Quinidine DerivativeSpirocyclization
Allylic Alkylation, (E)-1,3-diphenylallyl acetate, dimethyl malonate, dimethyl (R,E)-2-(1,3-diphenylallyl)malonate, Di-μ-chlorobis(η3-2-propenyl)dipalladium, (8α,9R)-9-[[(4S,5S)-4,5-Diphenyl-1,3,2-dioxaphospholan-2-yl]oxy]cinchonan, Cinchonidine DerivativeAlkylation, Allylic Alkylation
Oxysulfonylation, β,γ-unsaturated ketoximes, sulfonyl chlorides, sulfonyl-containing isoxazolines, cupric acetate, N-(8α,9S)-Cinchonan-9-yl-2,3,5,6-tetramethylbenzenesulfonamide, Cinchonidine DerivativeCyclization, Further reactions, Isoxazoline cyclization, Oxysulfonylation, Sulfonylation
Oxa-Michael, 2,4-disubstituted tert-butyl (Z)-4-oxobut-2-enoate, hydroxylamine, carboxy-substituted 2-isoxazolines, (1S,2R,4S,5R)-1-(2,5-bis(trifluoromethyl)benzyl)-2-((S)-hydroxy(6-methoxyquinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium bromide, Quinidine DerivativeCyclization, Isoxazoline cyclization, Michael Addition, Oxa-Michael Addition
Intramolecular Hydroarylation, 1-((2-(1-methyl-1H-indol-2-yl)phenyl)ethynyl)naphthalen-2-ol, 1-(11-methyl-11H-benzo[a]carbazol-6-yl)naphthalen-2-ol, Cinchonidine BaseCyclization, Further Cyclizations, Intramolecular cyclization
