Michael Addition, 2-enoylazaarenes, nitromethane, (R)-4-nitro-3-phenyl-1-(pyridin-2-yl)butan-1-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Michael Addition, substituted indolin-3-one, 2-hydroxynaphthalene-1,4-dione, acetyl chloride, substituted 1,4-dioxo-3-((3-oxoindolin-2-yl)methyl)-1,4-dihydronaphthalen-2-yl acetate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Cascade reaction, substituted tert-butyl (E)-2-(2-oxoindolin-3-ylidene)acetate, substituted 4-oxo-4H-chromene-3-carbaldehyde, nitromethane, spirocyclic compound, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Spirocyclization Cascade reaction, ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, pentane-2,4-dione, (E)-(2-nitrovinyl)benzene, poly-substituted spirocyclohexane oxindole, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Spirocyclization, substituted indoline-2-thione, E-substituted 3-vinylbenzo[d]isothiazole 1,1-dioxide, spiro[thiopyranoindole-benzoisothiazole]scaffold, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization Michael Addition, cyclohexane-1,3-dione, ethyl (E)-2-oxo-4-phenylbut-3-enoate, ethyl (4R)-2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate, (8α,9S)-(8′′α,9′′S)-9,9′′-[4,4′-bi-1H-1,2,3-triazole]-1,1′-diylbis[6′-methoxy-cinchonan, Quinine DerivativeMichael, Michael Addition α-Alkylation, ketones, diethyl 2-bromomalonate, diethyl (R)-2-(3,3-dimethyl-9-oxo-1,5-dioxaspiro[5.5]undecan-8-yl)malonate, (8α,9S)-6′-Methoxy-2′-phenylcinchonan-9-amine, Quinine DerivativeAlkylation, alpha-Alkylation Acylation, benzenesulfonimidamide, 2,2,2-trifluoroethyl 2,2,2-trifluoroacetate, (S)-N-(amino(oxo)(phenyl)-sulfaneylidene)-2,2,2-trifluoroacetamide, (8α,9R)-6′-methoxy-, 9-[P,P-bis(4-methoxyphenyl)phosphinate]cinchonan-9-ol, Quinine DerivativeAcylation, Further reactions Oxa-Michael, substituted (E)-4-methyl-N-(4-oxobut-2-en-1-yl)benzenesulfonamide, aldehydes, 2,5‐disubstituted oxazolidines, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition Aza-Michael Addition, substituted benzyl (E)-(7-(4-methoxyphenyl)-7-oxohept-5-en-1-yl)carbamate, substituted benzyl (R)-2-(2-(4-methoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Cyclization, Further Cyclizations, Intramolecular Aza-Michael, Intramolecular cyclization, Michael Addition« Older EntriesNext Entries »
Michael Addition, 2-enoylazaarenes, nitromethane, (R)-4-nitro-3-phenyl-1-(pyridin-2-yl)butan-1-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Michael Addition, substituted indolin-3-one, 2-hydroxynaphthalene-1,4-dione, acetyl chloride, substituted 1,4-dioxo-3-((3-oxoindolin-2-yl)methyl)-1,4-dihydronaphthalen-2-yl acetate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Cascade reaction, substituted tert-butyl (E)-2-(2-oxoindolin-3-ylidene)acetate, substituted 4-oxo-4H-chromene-3-carbaldehyde, nitromethane, spirocyclic compound, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction, Spirocyclization
Cascade reaction, ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, pentane-2,4-dione, (E)-(2-nitrovinyl)benzene, poly-substituted spirocyclohexane oxindole, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Spirocyclization, substituted indoline-2-thione, E-substituted 3-vinylbenzo[d]isothiazole 1,1-dioxide, spiro[thiopyranoindole-benzoisothiazole]scaffold, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization
Michael Addition, cyclohexane-1,3-dione, ethyl (E)-2-oxo-4-phenylbut-3-enoate, ethyl (4R)-2-hydroxy-5-oxo-4-phenyl-3,4,5,6,7,8-hexahydro-2H-chromene-2-carboxylate, (8α,9S)-(8′′α,9′′S)-9,9′′-[4,4′-bi-1H-1,2,3-triazole]-1,1′-diylbis[6′-methoxy-cinchonan, Quinine DerivativeMichael, Michael Addition
α-Alkylation, ketones, diethyl 2-bromomalonate, diethyl (R)-2-(3,3-dimethyl-9-oxo-1,5-dioxaspiro[5.5]undecan-8-yl)malonate, (8α,9S)-6′-Methoxy-2′-phenylcinchonan-9-amine, Quinine DerivativeAlkylation, alpha-Alkylation
Acylation, benzenesulfonimidamide, 2,2,2-trifluoroethyl 2,2,2-trifluoroacetate, (S)-N-(amino(oxo)(phenyl)-sulfaneylidene)-2,2,2-trifluoroacetamide, (8α,9R)-6′-methoxy-, 9-[P,P-bis(4-methoxyphenyl)phosphinate]cinchonan-9-ol, Quinine DerivativeAcylation, Further reactions
Oxa-Michael, substituted (E)-4-methyl-N-(4-oxobut-2-en-1-yl)benzenesulfonamide, aldehydes, 2,5‐disubstituted oxazolidines, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Cyclization, Further Cyclizations, Michael Addition, Oxa-Michael Addition
Aza-Michael Addition, substituted benzyl (E)-(7-(4-methoxyphenyl)-7-oxohept-5-en-1-yl)carbamate, substituted benzyl (R)-2-(2-(4-methoxyphenyl)-2-oxoethyl)piperidine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Cyclization, Further Cyclizations, Intramolecular Aza-Michael, Intramolecular cyclization, Michael Addition
