Desymmetrization, diolefinic diols, N-bromophthalimide, substituted ((3R,5S)-3-allyl-5-(bromomethyl)-tetrahydrofuran-3-yl)methanol, (9S)-9-[N-(4-ethoxyphenyl)carbamothioate]-6′-butoxy-cinchonan-9-ol, Cupreidine DerivativeCyclization, Cyclization, Desymmetrization, Further Cyclizations Michael Addition, 1,3-substituted (E)-4,4,4-trifluorobut-2-en-1-one, nitromethane, 1,3-substituted (S)-4,4,4-trifluoro-3-(nitromethyl)-butan-1-one, (9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-butoxy-6′-hydroxy-cinchonanium bromide, Cupreidine DerivativeMichael, Michael Addition Amination, α-substituted α-cyanoacetates, disubstituted (E)-diazene-1,2-dicarboxylate, substituted 1-(1-cyano-2-ethoxy-2-oxoethyl)hydrazine-1,2-dicarboxylate, (8α,9R)-9-(Phenylmethoxy)-cinchonan-6′-ol, Cupreine Derivativealpha-Amination, Amination Amination, α-substituted α-cyanoacetates, disubstituted (E)-diazene-1,2-dicarboxylate, substituted 1-(1-cyano-2-ethoxy-2-oxoethyl)hydrazine-1,2-dicarboxylate, (9S)-9-(phenylmethoxy)-cinchonan-6′-ol, Cupreidine Derivativealpha-Amination, Amination Cycloaddition, cyclic enones, azomethine imines, 9-substituted (4aR,8aR)-octahydro-3H,8H-pyrazolo[1,2-a]indazole-3,8-dione, (9R)-9-Aminocinchonan-6′-ol, Cupreidine Derivative1,3-Dipolar Cycloaddition, Cycloaddition Cycloaddition, diazo compounds, isoquinolinium methylides, [1,2,4] triazino [5,4-a] isoquinoline derivatives, (1S,2R,4S,5R)-2-((S)-(hexyloxy)(6-hydroxyquinolin-4-yl)methyl)-1-(2-methylbenzyl)-5-vinylquinuclidin-1-ium bromide, Cupreidine Derivative[3+3]-Cycloaddition, Cycloaddition Fluorination, N-(2-(5-mesityl-1-methyl-1H-indol-3-yl)ethyl)acetamide, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, 1-((3aR,8aS)-3a-fluoro-5-mesityl-8-methyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-1(2H)-yl)ethan-1-one, (8α,9R)-(8′′α,9′′R)-9,9′′-[1,4-Phthalazinediylbis (oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeFluorination, Fluorocyclization Conjugate Addition of phosphonates, (E)-1-(4-methoxyphenyl)but-2-en-1-one, diphenyl phosphonate, diphenyl (S)-(4-(4-methoxyphenyl)-4-oxobutan-2-yl)phosphonate, 2-[[[[3,5-Bis(1,1-dimethylethyl)phenyl]methyl]amino][[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]methylene]-Propanedinitrile, Dihydroquinine DerivativeConjugate addition of phosphonates, Further reactions Addition reaction, methyl 2-fluoro-3-((2-fluorophenyl)thio)-3-oxopropanoate, tert-butyl (E)-benzylidenecarbamate, methyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-fluoro-2-(((2-fluorophenyl)thio)carbonyl)-3-phenylpropanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeAddition Darzens reaction, 2-chloro-1-(4-chlorophenyl)ethan-1-one, 2-naphthaldehyde, (4-chlorophenyl)((2S,3R)-3-(naphthalen-2-yl)oxiran-2-yl)methanone, (1S,2R,4S,5R)-2-((S)-(6-hydroxyquinolin-4-yl)(phenanthren-9-yloxy)methyl)-1-(3,4,5-trifluorobenzyl)-5-vinylquinuclidin-1-ium bromide, Cupreidine DerivativeEpoxidation« Older EntriesNext Entries »
Desymmetrization, diolefinic diols, N-bromophthalimide, substituted ((3R,5S)-3-allyl-5-(bromomethyl)-tetrahydrofuran-3-yl)methanol, (9S)-9-[N-(4-ethoxyphenyl)carbamothioate]-6′-butoxy-cinchonan-9-ol, Cupreidine DerivativeCyclization, Cyclization, Desymmetrization, Further Cyclizations
Michael Addition, 1,3-substituted (E)-4,4,4-trifluorobut-2-en-1-one, nitromethane, 1,3-substituted (S)-4,4,4-trifluoro-3-(nitromethyl)-butan-1-one, (9S)-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-butoxy-6′-hydroxy-cinchonanium bromide, Cupreidine DerivativeMichael, Michael Addition
Amination, α-substituted α-cyanoacetates, disubstituted (E)-diazene-1,2-dicarboxylate, substituted 1-(1-cyano-2-ethoxy-2-oxoethyl)hydrazine-1,2-dicarboxylate, (8α,9R)-9-(Phenylmethoxy)-cinchonan-6′-ol, Cupreine Derivativealpha-Amination, Amination
Amination, α-substituted α-cyanoacetates, disubstituted (E)-diazene-1,2-dicarboxylate, substituted 1-(1-cyano-2-ethoxy-2-oxoethyl)hydrazine-1,2-dicarboxylate, (9S)-9-(phenylmethoxy)-cinchonan-6′-ol, Cupreidine Derivativealpha-Amination, Amination
Cycloaddition, cyclic enones, azomethine imines, 9-substituted (4aR,8aR)-octahydro-3H,8H-pyrazolo[1,2-a]indazole-3,8-dione, (9R)-9-Aminocinchonan-6′-ol, Cupreidine Derivative1,3-Dipolar Cycloaddition, Cycloaddition
Cycloaddition, diazo compounds, isoquinolinium methylides, [1,2,4] triazino [5,4-a] isoquinoline derivatives, (1S,2R,4S,5R)-2-((S)-(hexyloxy)(6-hydroxyquinolin-4-yl)methyl)-1-(2-methylbenzyl)-5-vinylquinuclidin-1-ium bromide, Cupreidine Derivative[3+3]-Cycloaddition, Cycloaddition
Fluorination, N-(2-(5-mesityl-1-methyl-1H-indol-3-yl)ethyl)acetamide, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, 1-((3aR,8aS)-3a-fluoro-5-mesityl-8-methyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-1(2H)-yl)ethan-1-one, (8α,9R)-(8′′α,9′′R)-9,9′′-[1,4-Phthalazinediylbis (oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeFluorination, Fluorocyclization
Conjugate Addition of phosphonates, (E)-1-(4-methoxyphenyl)but-2-en-1-one, diphenyl phosphonate, diphenyl (S)-(4-(4-methoxyphenyl)-4-oxobutan-2-yl)phosphonate, 2-[[[[3,5-Bis(1,1-dimethylethyl)phenyl]methyl]amino][[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]methylene]-Propanedinitrile, Dihydroquinine DerivativeConjugate addition of phosphonates, Further reactions
Addition reaction, methyl 2-fluoro-3-((2-fluorophenyl)thio)-3-oxopropanoate, tert-butyl (E)-benzylidenecarbamate, methyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-fluoro-2-(((2-fluorophenyl)thio)carbonyl)-3-phenylpropanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeAddition
Darzens reaction, 2-chloro-1-(4-chlorophenyl)ethan-1-one, 2-naphthaldehyde, (4-chlorophenyl)((2S,3R)-3-(naphthalen-2-yl)oxiran-2-yl)methanone, (1S,2R,4S,5R)-2-((S)-(6-hydroxyquinolin-4-yl)(phenanthren-9-yloxy)methyl)-1-(3,4,5-trifluorobenzyl)-5-vinylquinuclidin-1-ium bromide, Cupreidine DerivativeEpoxidation