Spirocyclization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, 4-fluorobenzaldehyde, ammonium acetate, diethyl (2’R,3R,4’R,5’R)-2′-(4-fluorophenyl)-1-methyl-2,6′-dioxospiro[indoline-3,3′-piperidine]-4′,5′-dicarboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeSpirocyclization Cyclization, (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one, nitromethane, (3R,5R)-4-(nitromethyl)-3,5-diphenylcyclohexan-1-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCyclization, Cycloaddition Addition, dimethyl (E)-but-2-enoylphosphonate, 2-(2-bromophenyl)-4-isopropyloxazol-5(4H)-one, methanol, methyl (R)-3-((R)-2-(2-bromophenyl)-4-isopropyl-5-oxo-2,5-dihydrooxazol-2-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAddition Fluorination, protected piperidin-4-one, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, cis-3-fluoropiperidin-4-ol, trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Fluorination, Fluorination Addition of Thiols, ketimines, thiols, substituted (R)-3-amino-3-mercaptoindolin-2-one, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-2-Pyridinesulfonamide, Quinine DerivativeAddition Cyclization, cyclic trifluoromethyl ketimines, alcohols, chiral N,O-ketals, chiral ethers, caesium carbonate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Further Cyclizations Aza-Michael Addition, tert-butyl (naphthalen-2-ylmethoxy)carbamate, (E)-1-(4-Methoxyphenyl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one, (R)-tert-Butyl-(4-(4-Methoxyphenyl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)(naphthalen-2-ylmethoxy)carbamate, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]- 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide, Quinine DerivativeAza-Michael, Michael Addition Spirocyclization, substituted penta-1,4-dien-3-one, oxindoles, Spiro [cyclohexanone‐oxindoles], N-tert-Butoxycarbonyl-D-phenylglycine, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization Cycloaddition, 2,3-disubstituted indoles, methyl vinyl ketone, substituted (4aR,9aR)-9-(3-oxobutyl)-3,4-dihydro-9H-4a,9a-butanocarbazol-2(1H)-one, pentafluorobenzoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivative[4+2]-Cycloaddition, Cycloaddition, Diels-Alder reaction Spirocyclization, unsaturated pyrazolones, unsaturated ketones, susbtituted 4-methyl-2-phenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization« Older EntriesNext Entries »
Spirocyclization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, 4-fluorobenzaldehyde, ammonium acetate, diethyl (2’R,3R,4’R,5’R)-2′-(4-fluorophenyl)-1-methyl-2,6′-dioxospiro[indoline-3,3′-piperidine]-4′,5′-dicarboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeSpirocyclization
Cyclization, (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one, nitromethane, (3R,5R)-4-(nitromethyl)-3,5-diphenylcyclohexan-1-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCyclization, Cycloaddition
Addition, dimethyl (E)-but-2-enoylphosphonate, 2-(2-bromophenyl)-4-isopropyloxazol-5(4H)-one, methanol, methyl (R)-3-((R)-2-(2-bromophenyl)-4-isopropyl-5-oxo-2,5-dihydrooxazol-2-yl)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAddition
Fluorination, protected piperidin-4-one, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, cis-3-fluoropiperidin-4-ol, trichloroacetic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivativealpha-Fluorination, Fluorination
Addition of Thiols, ketimines, thiols, substituted (R)-3-amino-3-mercaptoindolin-2-one, N-[(8α,9S)-6′-methoxycinchonan-9-yl]-2-Pyridinesulfonamide, Quinine DerivativeAddition
Cyclization, cyclic trifluoromethyl ketimines, alcohols, chiral N,O-ketals, chiral ethers, caesium carbonate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Further Cyclizations
Aza-Michael Addition, tert-butyl (naphthalen-2-ylmethoxy)carbamate, (E)-1-(4-Methoxyphenyl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one, (R)-tert-Butyl-(4-(4-Methoxyphenyl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)(naphthalen-2-ylmethoxy)carbamate, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]- 1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide, Quinine DerivativeAza-Michael, Michael Addition
Spirocyclization, substituted penta-1,4-dien-3-one, oxindoles, Spiro [cyclohexanone‐oxindoles], N-tert-Butoxycarbonyl-D-phenylglycine, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization
Cycloaddition, 2,3-disubstituted indoles, methyl vinyl ketone, substituted (4aR,9aR)-9-(3-oxobutyl)-3,4-dihydro-9H-4a,9a-butanocarbazol-2(1H)-one, pentafluorobenzoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine Derivative[4+2]-Cycloaddition, Cycloaddition, Diels-Alder reaction
Spirocyclization, unsaturated pyrazolones, unsaturated ketones, susbtituted 4-methyl-2-phenyl-2,3-diazaspiro[4.5]dec-3-ene-1,8-dione, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeSpirocyclization
