Oxa-Michael, substituted cyclopropylbenzene, cyclopropane-fused chromanol structure, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Oxa-Michael Addition Epoxidation, (E)-chalcone, hydrogen peroxide, phenyl((2S,3R)-3-phenyloxiran-2-yl)methanone, (8α,9R)-(8′′α,9′′R)-1,1′′-[(2-fluoro-1,3-phenylene)bis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium dibromide, Quinine DerivativeEpoxidation Epoxidation, α,β-unsaturated ketones, hydrogen peroxide, epoxy ketones, (8α,9R)-(8′′α,9′′R)-1,1′′-[(2-fluoro-1,3-phenylene)bis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium dibromide, Quinine DerivativeEpoxidation Allylation, 3-phenylpropanal, allyltrichlorosilane, (S)-1-phenylhex-5-en-3-ol, N-[(8α,9S)-10,11-dihydro-6′-methoxy-11-[[3-(trimethoxysilyl)propyl]thio]cinchonan-9-yl]-4-(dimethylamino)benzamide, Quinine DerivativeAlkylation, Allylation Hydrogenation, ethyl (Z)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)acrylate, trichlorosilane, ethyl (S)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)propanoate, N-[(8α,9R)-6′-methoxycinchonan-9-yl]-2-pyridinecarboxamide, Quinine DerivativeHydrogenation Isoxazoline cyclization, (R,E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide, hydroxylamine, Optically Enriched Isoxazolines, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization Mannich reaction, 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine, malonates, aldehydes, 2-(((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich Nazarov cyclization, methyl 2-diazo-2-phenylacetate, (E)-4-methyl-1-phenylhex-4-en-1-yn-3-ol, (S)-5-hydroxy-2,3-dimethyl-5-phenyl-4-((R)-2-phenylvinylidene)cyclopent-2-en-1-one, N,N′-bis[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivatveCyclization, Further Cyclizations, Nazarov cyclization Lactonization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, formaldehyde, tetrahydropyranone spirooxindole, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivatveLactonization, Spirocyclization Aza-Henry (Nitro-Mannich), diethyl 2-fluoromalonate, (E)-(2-nitrovinyl)benzene, 4-bromobenzaldehyde, ammonium acetate, ethyl (3S,4S,5S,6R)-6-(4-bromophenyl)-3-fluoro-5-nitro-2-oxo-4-phenylpiperidine-3-carboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich« Older EntriesNext Entries »
Oxa-Michael, substituted cyclopropylbenzene, cyclopropane-fused chromanol structure, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael Addition, Oxa-Michael Addition
Epoxidation, (E)-chalcone, hydrogen peroxide, phenyl((2S,3R)-3-phenyloxiran-2-yl)methanone, (8α,9R)-(8′′α,9′′R)-1,1′′-[(2-fluoro-1,3-phenylene)bis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium dibromide, Quinine DerivativeEpoxidation
Epoxidation, α,β-unsaturated ketones, hydrogen peroxide, epoxy ketones, (8α,9R)-(8′′α,9′′R)-1,1′′-[(2-fluoro-1,3-phenylene)bis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium dibromide, Quinine DerivativeEpoxidation
Allylation, 3-phenylpropanal, allyltrichlorosilane, (S)-1-phenylhex-5-en-3-ol, N-[(8α,9S)-10,11-dihydro-6′-methoxy-11-[[3-(trimethoxysilyl)propyl]thio]cinchonan-9-yl]-4-(dimethylamino)benzamide, Quinine DerivativeAlkylation, Allylation
Hydrogenation, ethyl (Z)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)acrylate, trichlorosilane, ethyl (S)-3-(4-(benzyloxy)phenyl)-3-((4-fluorophenyl)amino)propanoate, N-[(8α,9R)-6′-methoxycinchonan-9-yl]-2-pyridinecarboxamide, Quinine DerivativeHydrogenation
Isoxazoline cyclization, (R,E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl)-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2-methylbenzamide, hydroxylamine, Optically Enriched Isoxazolines, 1,1′′-[9,10-anthracenediylbis(methylene)]bis[9-hydroxy-6′-methoxy-cinchonanium chloride, Quinine DerivativeCyclization, Isoxazoline cyclization
Mannich reaction, 4-methyl-6-(piperidin-1-yl)pyrimidin-2-amine, malonates, aldehydes, 2-(((4-methyl-6-(piperidin-1-yl)pyrimidin-2-yl)amino)methyl)malonates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich
Nazarov cyclization, methyl 2-diazo-2-phenylacetate, (E)-4-methyl-1-phenylhex-4-en-1-yn-3-ol, (S)-5-hydroxy-2,3-dimethyl-5-phenyl-4-((R)-2-phenylvinylidene)cyclopent-2-en-1-one, N,N′-bis[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivatveCyclization, Further Cyclizations, Nazarov cyclization
Lactonization, ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, diethyl malonate, formaldehyde, tetrahydropyranone spirooxindole, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivatveLactonization, Spirocyclization
Aza-Henry (Nitro-Mannich), diethyl 2-fluoromalonate, (E)-(2-nitrovinyl)benzene, 4-bromobenzaldehyde, ammonium acetate, ethyl (3S,4S,5S,6R)-6-(4-bromophenyl)-3-fluoro-5-nitro-2-oxo-4-phenylpiperidine-3-carboxylate, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
