C-N bond cleavage, 1,3-dimethyl-5-tosylbenzo[k]phenanthridin-6(5H)-one, 3-oxo-3-(pyrrolidin-1-yl)propanenitrile, N-(3,5-dimethyl-2-(2-(4-(pyrrolidine-1-carbonyl)oxazol-5-yl)naphthalen-1-yl)phenyl)-4-methylbenzenesulfonamide, silver carbonate, 3-[(1,1-Dimethylethyl)amino]-4-[[(8α,9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeC-N bond cleavage, Further reactions Cyanation, α-ketophosphonates, trimethylsilyl cyanide, tertiary α-hydroxy phosphonates, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-N′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-thiourea, Quinine DerivativeCyanation Sulfenylation, azlactones, N-(sulfanyl) succinimides, α-sulfenylated azlactones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSulfenylation Desymmetrization, (3aR,7aS)-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione, methanol, (1S,6R)-6-(methoxycarbonyl)cyclohex-3-ene-1-carboxylic acid, 4-ethenyl-N-[(S)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxy-4-quinolinyl)methyl]-benzenesulfonamide, Quinine DerivativeDesymmetrization Bromohydroxylation, N-bromosuccinimide, phenylboronic acid, 2-(3-methoxyphenyl)prop-2-en-1-ol, (S)-3-bromo-2-(3-methoxyphenyl)propane-1,2-diol, 4-Methoxy-N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzenesulfonamide, Quinine DerivativeBromination, Bromohydroxylation Cyclopropantion, 3-chloro-1-ethylindolin-2-one, 2-benzylidene-1H-indene-1,3(2H)-dione, (2’R,3’S)-1”-ethyl-3′-phenyldispiro[indene-2,1′-cyclopropane-2′,3”-indoline]-1,2”,3-trione, N-[(1R,2S)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl] thiourea, Quinine DerivativeCyclopropanation, Spirocyclization Bromination, allylic sulfonamides, N-bromsuccinimid, benzoic acid, 1-substituted (1R,2S)-2-bromo-3-((trifluoromethyl)sulfonamido)propyl benzoate, camphorsulfonic acid, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeBromination Cascade reaction, (E)-2-oxo-4-styryl-2H-chromene-3-carbonitrile, 2-mercapto-1-phenylethan-1-one, (1R,3aR,11cR)-5-imino-1,3a-diphenyl-3,3a,5,11c-tetrahydro-1H,6H-thieno[3′,4′:5,6]pyrano[3,4-c]chromen-6-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction Cascade reaction, cyclohex-2-en-1-one, 1-(benzo[d]thiazol-2-ylsulfonyl)-4-phenylbutan-2-one, (1S,4S)-6-phenethylbicyclo[2.2.2]oct-5-en-2-one, (8α,9S)-6′-methoxy-Cinchonan-9-amine 2,2,2-trifluoroacetate (1:2), Quinine DerivativeCascade reaction Semipinacol Rearrangement, substituted prop-2-en-1-ol, N-bromsuccinimid, substituted (4s) 4-bromobutan-2-one, 3,4-dimethoxybenzoic acid, (9S)-(9′′S)-9,9′′-[3,6-pyridazinediylbis(oxy)]bis[10,11- dihydro-6′-methoxy-cinchonan, Dihydroquinidine DerivativeBromination, Semipinacol Rearrangement« Older EntriesNext Entries »
C-N bond cleavage, 1,3-dimethyl-5-tosylbenzo[k]phenanthridin-6(5H)-one, 3-oxo-3-(pyrrolidin-1-yl)propanenitrile, N-(3,5-dimethyl-2-(2-(4-(pyrrolidine-1-carbonyl)oxazol-5-yl)naphthalen-1-yl)phenyl)-4-methylbenzenesulfonamide, silver carbonate, 3-[(1,1-Dimethylethyl)amino]-4-[[(8α,9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeC-N bond cleavage, Further reactions
Cyanation, α-ketophosphonates, trimethylsilyl cyanide, tertiary α-hydroxy phosphonates, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-N′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-thiourea, Quinine DerivativeCyanation
Sulfenylation, azlactones, N-(sulfanyl) succinimides, α-sulfenylated azlactones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSulfenylation
Desymmetrization, (3aR,7aS)-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione, methanol, (1S,6R)-6-(methoxycarbonyl)cyclohex-3-ene-1-carboxylic acid, 4-ethenyl-N-[(S)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxy-4-quinolinyl)methyl]-benzenesulfonamide, Quinine DerivativeDesymmetrization
Bromohydroxylation, N-bromosuccinimide, phenylboronic acid, 2-(3-methoxyphenyl)prop-2-en-1-ol, (S)-3-bromo-2-(3-methoxyphenyl)propane-1,2-diol, 4-Methoxy-N-[(8α,9S)-6′-methoxycinchonan-9-yl]benzenesulfonamide, Quinine DerivativeBromination, Bromohydroxylation
Cyclopropantion, 3-chloro-1-ethylindolin-2-one, 2-benzylidene-1H-indene-1,3(2H)-dione, (2’R,3’S)-1”-ethyl-3′-phenyldispiro[indene-2,1′-cyclopropane-2′,3”-indoline]-1,2”,3-trione, N-[(1R,2S)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl] thiourea, Quinine DerivativeCyclopropanation, Spirocyclization
Bromination, allylic sulfonamides, N-bromsuccinimid, benzoic acid, 1-substituted (1R,2S)-2-bromo-3-((trifluoromethyl)sulfonamido)propyl benzoate, camphorsulfonic acid, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeBromination
Cascade reaction, (E)-2-oxo-4-styryl-2H-chromene-3-carbonitrile, 2-mercapto-1-phenylethan-1-one, (1R,3aR,11cR)-5-imino-1,3a-diphenyl-3,3a,5,11c-tetrahydro-1H,6H-thieno[3′,4′:5,6]pyrano[3,4-c]chromen-6-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction
Cascade reaction, cyclohex-2-en-1-one, 1-(benzo[d]thiazol-2-ylsulfonyl)-4-phenylbutan-2-one, (1S,4S)-6-phenethylbicyclo[2.2.2]oct-5-en-2-one, (8α,9S)-6′-methoxy-Cinchonan-9-amine 2,2,2-trifluoroacetate (1:2), Quinine DerivativeCascade reaction
Semipinacol Rearrangement, substituted prop-2-en-1-ol, N-bromsuccinimid, substituted (4s) 4-bromobutan-2-one, 3,4-dimethoxybenzoic acid, (9S)-(9′′S)-9,9′′-[3,6-pyridazinediylbis(oxy)]bis[10,11- dihydro-6′-methoxy-cinchonan, Dihydroquinidine DerivativeBromination, Semipinacol Rearrangement
