Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation Friedel-Crafts Alkylation, 1-bromo1-nitroalkenes, 1H-indol-4-ol, 3-substituted (R)-2-nitro-3,6-dihydro-2H-furo[2,3-e]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation Mannich reaction, substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines, trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives, 3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Mannich, Mannich Mannich reaction, 2-pyridyl N-oxide acetates, N-Boc imines, α- and β-functionalized 2-substituted pyridines, Phenylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich Mannich reaction, imines, sulfonylacetonitriles, β-amino nitriles, 9H-Fluoren-9-ylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich Sulfa-Michael Addition, aromatic thiols, nitroalkenes, 2-nitro-1-arylethyl sulfides, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition [4+2]-Annulation, 3-nitroindoles, Nazarov reagents, hydrocarbazoles, (αS)-α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzenepropanamide, Quinine Derivative[4+2] Annulation, Cyclization, Further Cyclizations Michael Addition, 3-substituted phthalides, nitroolefins, 3,3-disubstituted phthalide derivatives, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael, Michael Addition Cyclopropanation, oxindoles, bromonitroolefins, 3-spirocyclopropyl-2-oxindoles, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeCyclopropanation, Spirocyclization [3+1]-Annulation, 3-chloro-1-methylindolin-2-one, benzoyl(3,4-dihydroisoquinolin-2-ium-2-yl)amide, (3S,3aR,8aS)-2-benzoyl-1′-methyl-1,3a,8,8a-tetrahydro-2H-spiro[indeno[2,1-c]pyrazole-3,3′-indolin]-2′-one, 6-Chloro-1-hydroxybenzotriazole, N-[(1R,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine Derivative[3+1]-Annulation, Cyclization, Further Cyclizations« Older EntriesNext Entries »
Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation
Friedel-Crafts Alkylation, 1-bromo1-nitroalkenes, 1H-indol-4-ol, 3-substituted (R)-2-nitro-3,6-dihydro-2H-furo[2,3-e]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation
Mannich reaction, substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines, trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives, 3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Mannich, Mannich
Mannich reaction, 2-pyridyl N-oxide acetates, N-Boc imines, α- and β-functionalized 2-substituted pyridines, Phenylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich
Mannich reaction, imines, sulfonylacetonitriles, β-amino nitriles, 9H-Fluoren-9-ylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich
Sulfa-Michael Addition, aromatic thiols, nitroalkenes, 2-nitro-1-arylethyl sulfides, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
[4+2]-Annulation, 3-nitroindoles, Nazarov reagents, hydrocarbazoles, (αS)-α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzenepropanamide, Quinine Derivative[4+2] Annulation, Cyclization, Further Cyclizations
Michael Addition, 3-substituted phthalides, nitroolefins, 3,3-disubstituted phthalide derivatives, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael, Michael Addition
Cyclopropanation, oxindoles, bromonitroolefins, 3-spirocyclopropyl-2-oxindoles, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeCyclopropanation, Spirocyclization
[3+1]-Annulation, 3-chloro-1-methylindolin-2-one, benzoyl(3,4-dihydroisoquinolin-2-ium-2-yl)amide, (3S,3aR,8aS)-2-benzoyl-1′-methyl-1,3a,8,8a-tetrahydro-2H-spiro[indeno[2,1-c]pyrazole-3,3′-indolin]-2′-one, 6-Chloro-1-hydroxybenzotriazole, N-[(1R,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine Derivative[3+1]-Annulation, Cyclization, Further Cyclizations
