Trifluoromethylation, (E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime, (S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Isoxazoline cyclization, Trifluoromethylation Oxa-Michael Addition, methyl (E)-4-(2-hydroxyphenyl)but-2-enoate, methyl 2-(2,3-dihydrobenzofuran-2-yl)acetate, Dihydrocinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, intramolecular Oxa-Michael Addition, Michael Addition, Oxa-Michael Addition Sulfa-Michael Addition, α,β-unsaturated N-acylated oxazolidin-2-ones, alkyl thiols, γ-thio ketones, N-[(9S)-9-(9-anthracenylmethoxy)cinchonan-6′-yl]-N′-[3,5-bis(trifluoromethyl)phenyl]-thiourea, 6´-Aminocinchonine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Michael Addition, thioester malonates, (E)-1-((4-methoxybenzyl)oxy)-2-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3S)-3-(2-((4-methoxybenzyl)oxy)phenyl)-2-(((4-methoxyphenyl)thio)carbonyl)-2-methyl-4-nitrobutanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition Michael Addition, 4-methoxyphenyl 3-((4-methoxyphenyl)thio)-2-methyl-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, acyclic γ-nitrothioesters, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition Michael Addition, 1H-pyrrole, α,β-unsaturated ketones, 2-substituted pyrroles, (9R)-Cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition Michael Addition, 2-enoylpyridines, malononitrile, 1-substituted 2-(3-oxo-3-(pyridin-2-yl)propyl)malononitrile, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition Aldol reaction, β,γ‐unsaturated α‐keto esters, cyclohexanone, methyl (R,E)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-3-enoate, (9R)-Cinchonan-9-amine, Cinchonine DerivativeAldol, Aldol Spirocyclization, N-protected [3,3′-biindoline]-2,2′-dione, formaldehyde, N-protected (3R)-4-(2-aminophenyl)-2H-spiro[furan-3,3′-indoline]-2′,5(4H)-dione, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeAldol, Aldol, Spirocyclization Spirocyclization, N-2,2,2-trifluoroethylisatin ketimines, unsymmetrical dicarbonyl-activated alkenes, 5′-trifluoromethylated 3,2′-pyrrolidinyl spirooxindoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine DerivativeSpirocyclization« Older EntriesNext Entries »
Trifluoromethylation, (E)-1-(3-bromophenyl)-3-phenylbut-3-en-1-one oxime, (S)-3-(3-bromophenyl)-5-phenyl-5-(2,2,2-trifluoroethyl)-4,5-dihydroisoxazole, copper acetate, N-[(9R)-10,11-dihydrocinchonan-9-yl]-2,3,4,5,6-pentamethyl-benzenesulfonamide, Dihydrocinchonine DerivativeCyclization, Fluorination, Fluoromethylation, Isoxazoline cyclization, Trifluoromethylation
Oxa-Michael Addition, methyl (E)-4-(2-hydroxyphenyl)but-2-enoate, methyl 2-(2,3-dihydrobenzofuran-2-yl)acetate, Dihydrocinchonine BaseCyclization, Further Cyclizations, Intramolecular cyclization, intramolecular Oxa-Michael Addition, Michael Addition, Oxa-Michael Addition
Sulfa-Michael Addition, α,β-unsaturated N-acylated oxazolidin-2-ones, alkyl thiols, γ-thio ketones, N-[(9S)-9-(9-anthracenylmethoxy)cinchonan-6′-yl]-N′-[3,5-bis(trifluoromethyl)phenyl]-thiourea, 6´-Aminocinchonine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Michael Addition, thioester malonates, (E)-1-((4-methoxybenzyl)oxy)-2-(2-nitrovinyl)benzene, 4-methoxybenzyl (2S,3S)-3-(2-((4-methoxybenzyl)oxy)phenyl)-2-(((4-methoxyphenyl)thio)carbonyl)-2-methyl-4-nitrobutanoate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, 4-methoxyphenyl 3-((4-methoxyphenyl)thio)-2-methyl-3-oxopropanoate, (E)-(2-nitrovinyl)benzene, acyclic γ-nitrothioesters, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, 1H-pyrrole, α,β-unsaturated ketones, 2-substituted pyrroles, (9R)-Cinchonan-9-amine, Cinchonine DerivativeMichael, Michael Addition
Michael Addition, 2-enoylpyridines, malononitrile, 1-substituted 2-(3-oxo-3-(pyridin-2-yl)propyl)malononitrile, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-urea, Cinchonine DerivativeMichael, Michael Addition
Aldol reaction, β,γ‐unsaturated α‐keto esters, cyclohexanone, methyl (R,E)-2-hydroxy-2-((S)-2-oxocyclohexyl)-4-phenylbut-3-enoate, (9R)-Cinchonan-9-amine, Cinchonine DerivativeAldol, Aldol
Spirocyclization, N-protected [3,3′-biindoline]-2,2′-dione, formaldehyde, N-protected (3R)-4-(2-aminophenyl)-2H-spiro[furan-3,3′-indoline]-2′,5(4H)-dione, N-[3,5-bis(trifluoromethyl)phenyl]-N′-(9R)-cinchonan-9-yl-thiourea, Cinchonine DerivativeAldol, Aldol, Spirocyclization
Spirocyclization, N-2,2,2-trifluoroethylisatin ketimines, unsymmetrical dicarbonyl-activated alkenes, 5′-trifluoromethylated 3,2′-pyrrolidinyl spirooxindoles, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine DerivativeSpirocyclization
