Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH) Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization Michael Addition, (E)-(2-nitrovinyl)benzene, S,S-diphenyl propanebis(thioate), S,S-diphenyl 2-(2-nitro-1-phenylethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Cyclization, (2E,2’E)-3,3′-(1,2-phenylene)bis(1-(4-methoxyphenyl)prop-2-en-1-one), hydrazine hydrate, pyrazolines, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Cyclization, substituted phenylaminomaleate, substituted 2-methylenemalononitrile, chiral 1, 4-dihydropyridine derivatives, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Michael Addition, α-aryl isocyanoacetates, β-trifluoromethylated enones, substituted (3S)-2-isocyano-5-oxo-3-(trifluoromethyl)pentanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Vinylogous Aldol, aldehydes, 3,4,5-trisubstituted furan-2(3H)-one, substituted 5-(hydroxymethyl)furan-2(5H)-one, N-[(2S)-2-[[2-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3-phenylpropyl]-1,1,2,2,3,3,4,4,4-nonafluoro-1-Butanesulfonamide, Dihydroquinine DerivativeAldol, Vinylogous Aldol Aza-Henry, substituted 1-benzyl-3-iminoindolinone, primary nitroalkanes, substituted (R)-3-amino-1-benzyl-3-((R)-1-nitroethyl)indolin-2-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[(1S)-1-hydroxy-2-phenylethyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Mannich reaction, substituted 2-isocyanoacetate, 4-substituted 2-methyl-1,2,5-thiadiazol-3(2H)-one 1,1-dioxide, substituted (4S)-2-methyl-3-oxo-2,3,3a,4-tetrahydroimidazo[1,5-b][1,2,5]thiadiazole-4-carboxylate 1,1-dioxide, silver acetate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich Michael Addition, nitroalkenes, S,S-diethyl propanebis(thioate), substituted S,S-diethyl 2-(2-nitroethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition« Older EntriesNext Entries »
Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH)
Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
Michael Addition, (E)-(2-nitrovinyl)benzene, S,S-diphenyl propanebis(thioate), S,S-diphenyl 2-(2-nitro-1-phenylethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Cyclization, (2E,2’E)-3,3′-(1,2-phenylene)bis(1-(4-methoxyphenyl)prop-2-en-1-one), hydrazine hydrate, pyrazolines, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Cyclization, substituted phenylaminomaleate, substituted 2-methylenemalononitrile, chiral 1, 4-dihydropyridine derivatives, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Michael Addition, α-aryl isocyanoacetates, β-trifluoromethylated enones, substituted (3S)-2-isocyano-5-oxo-3-(trifluoromethyl)pentanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Vinylogous Aldol, aldehydes, 3,4,5-trisubstituted furan-2(3H)-one, substituted 5-(hydroxymethyl)furan-2(5H)-one, N-[(2S)-2-[[2-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3-phenylpropyl]-1,1,2,2,3,3,4,4,4-nonafluoro-1-Butanesulfonamide, Dihydroquinine DerivativeAldol, Vinylogous Aldol
Aza-Henry, substituted 1-benzyl-3-iminoindolinone, primary nitroalkanes, substituted (R)-3-amino-1-benzyl-3-((R)-1-nitroethyl)indolin-2-one, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-N′-[(1S)-1-hydroxy-2-phenylethyl]-thiourea, Dihydroquinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Mannich reaction, substituted 2-isocyanoacetate, 4-substituted 2-methyl-1,2,5-thiadiazol-3(2H)-one 1,1-dioxide, substituted (4S)-2-methyl-3-oxo-2,3,3a,4-tetrahydroimidazo[1,5-b][1,2,5]thiadiazole-4-carboxylate 1,1-dioxide, silver acetate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMannich, Mannich
Michael Addition, nitroalkenes, S,S-diethyl propanebis(thioate), substituted S,S-diethyl 2-(2-nitroethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
