Domino Michael, α-nitroketones, γ/δ-hydroxyenones, ß-nitro-γ/δ-hydroxyketones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Mannich reaction, dihydro‐3‐carboalkoxy‐2‐quinolones, tert-butyloxycarbonyl protected imines, substituted (S)-3-(((tert-butoxycarbonyl)amino)methyl)-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative Aza-Henry (Nitro-Mannich), substituted 3H-indole, nitroalkanes, substituted (R)-2-(nitromethyl)indoline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Spirocyclization, 2-methoxy-6-(phenyl(tosyl)methyl)phenol, 4-bromo-2-(3-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, spirobenzofuranpyrazolones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization Pictet-Sprengler, 2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)ethan-1-amine, benzaldehyde, (R)-2-(naphthalen-2-ylmethyl)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction Mannich reaction, pyrazolamides, cyclic trifluoromethylketimines, (S)-6-chloro-1-(4-methoxybenzyl)-4-((S)-2-oxo-2-(1H-pyrazol-1-yl)-1-(p-tolyl)ethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Mannich reaction, 5-(4-chlorophenyl)-1,3,4-thiadiazol-2-amine, 2,3-dichlorobenzaldehyde, diethyl malonate, diethyl 2-(((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)amino)(2,3-dichlorophenyl)-l3-methyl)malonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Mannich reaction, imines, dithiomalonates, S,S-dibenzyl (S)-2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich Cyclization, substituted 1-benzylquinolin-1-ium, substituted (E)-4-(2-hydroxyphenyl)but-3-en-2-one, substituted (3aS,3a1R,8aS,13bR)-9-benzyl-3,3a,3a1,8a,9,13b-hexahydrochromeno[2,3,4-gh]phenanthridin-2(1H)-one, mandelic acid, 3-methyl-D-Valine (9S)-6′-methoxycinchonan-9-yl ester, Quinine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations Mannich reaction, α-ketoamides, p-nosylimines, substituted 3-hydroxy-4-((4-nitrophenyl)sulfonamido)-2-oxobutanamide, N-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-N-(phenylmethyl)-5-(trifluoromethyl)-benzamide, Quinine DerivativeMannich, Mannich« Older EntriesNext Entries »
Domino Michael, α-nitroketones, γ/δ-hydroxyenones, ß-nitro-γ/δ-hydroxyketones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Mannich reaction, dihydro‐3‐carboalkoxy‐2‐quinolones, tert-butyloxycarbonyl protected imines, substituted (S)-3-(((tert-butoxycarbonyl)amino)methyl)-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative
Aza-Henry (Nitro-Mannich), substituted 3H-indole, nitroalkanes, substituted (R)-2-(nitromethyl)indoline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Spirocyclization, 2-methoxy-6-(phenyl(tosyl)methyl)phenol, 4-bromo-2-(3-bromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one, spirobenzofuranpyrazolones, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSpirocyclization
Pictet-Sprengler, 2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)ethan-1-amine, benzaldehyde, (R)-2-(naphthalen-2-ylmethyl)-1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction
Mannich reaction, pyrazolamides, cyclic trifluoromethylketimines, (S)-6-chloro-1-(4-methoxybenzyl)-4-((S)-2-oxo-2-(1H-pyrazol-1-yl)-1-(p-tolyl)ethyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Mannich reaction, 5-(4-chlorophenyl)-1,3,4-thiadiazol-2-amine, 2,3-dichlorobenzaldehyde, diethyl malonate, diethyl 2-(((5-(4-chlorophenyl)-1,3,4-thiadiazol-2-yl)amino)(2,3-dichlorophenyl)-l3-methyl)malonate, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Mannich reaction, imines, dithiomalonates, S,S-dibenzyl (S)-2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeMannich, Mannich
Cyclization, substituted 1-benzylquinolin-1-ium, substituted (E)-4-(2-hydroxyphenyl)but-3-en-2-one, substituted (3aS,3a1R,8aS,13bR)-9-benzyl-3,3a,3a1,8a,9,13b-hexahydrochromeno[2,3,4-gh]phenanthridin-2(1H)-one, mandelic acid, 3-methyl-D-Valine (9S)-6′-methoxycinchonan-9-yl ester, Quinine DerivativeCascade reaction, Cyclization, Cyclization, Further Cyclizations
Mannich reaction, α-ketoamides, p-nosylimines, substituted 3-hydroxy-4-((4-nitrophenyl)sulfonamido)-2-oxobutanamide, N-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-N-(phenylmethyl)-5-(trifluoromethyl)-benzamide, Quinine DerivativeMannich, Mannich
