Spirocyclization, substituted (Z)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted 1-methyl-3-methyleneindolin-2-one, substituted (3R,3’R,5’S)-1”-methyl-5′-(trifluoromethyl)dispiro[indoline-3,2′-pyrrolidine-3′,3”-indoline]-2,2”-dione, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[[(1R)-1-phenylethyl]amino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeSpirocyclization Spirocyclization, substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted (E)-nitroethene, substituted (3R,3’R,5’R)-3′-nitro-5′-(trifluoromethyl)spiro[indoline-3,2′-pyrrolidin]-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonidine DerivativeSpirocyclization Hydrophosphonylation, 1-benzyl-3-iminoindolin-2-one, phosphonic acid ester, (R)-(3-amino-1-benzyl-2-oxoindolin-3-yl)phosphonic acid ester, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(4-methoxyphenyl)amino]-3-cyclobutene-1,2-dione, Cinchonidine DerivativeHydrophosphonylation Aza-Michael Addition, (E)-3-(1-methylindolin-2-yl)-1-phenylprop-2-en-1-one, 4-phenyl-1-(phenylsulfonyl)-1H-1,2,3-triazole, 2-((1R)-9-methyl-4-phenyl-2-(phenylsulfonyl)-2,4a,9,9a-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-1-phenylethan-1-one, rhodium(II) acetate, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(phenylmethyl)amino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeAza-Michael, Michael Addition [4+2] Annulation, substituted benzo[e][1,2,3]oxathiazine 2,2-dioxide, substituted (E)-pent-2-en-1-one, 1,3‐oxazinanes, hexahydropyrimidines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine Derivative[4+2] Annulation, Cyclization, Further Cyclizations Desymmetrization, tert-butyl 7-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 1-(2-(tert-butyl)phenyl)-1H-pyrrole-2,5-dione, tert-butyl (R)-3-((S)-1-(2-(tert-butyl)phenyl)-2,5-dioxopyrrolidin-3-yl)-7-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeAtropisomer synthesis, Desymmetrization Spirocyclization, N-substituted (Z)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, Aryl substituted alkenes, substituted (3S,5’S)-5′-(trifluoromethyl)spiro[indoline-3,2′-pyrrolidin]-2-one, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeSpirocyclization Cascade reaction, substituted 2-mercaptobenzaldehyde, substituted 1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)prop-2-en-1-one, substituted (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)((3S,4R)-4-hydroxythiochroman-3-yl)methanone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeCascade reaction Cascade reaction, substituted (E)-3-trifluoromethyl-3-(1H-indol-3-yl)-1-phenylprop-2-en-1-one, substituted 2-mercaptobenzaldehyde, substituted ((2R,3S,4R)-4-hydroxy-2-((S)-indolin-3-yl)-2-(trifluoromethyl)thiochroman-3-yl)(phenyl)methanone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeCascade reaction Pictet-Spengler Reaction, (E)-tert-butyl (4-((2-(4-methoxy-1H-indol-3-yl)ethyl)amino)but-2-en-1-yl) carbonate, methyl 2,2-bis(ethylthio)-5-oxopentanoate, methyl (S,E)-4-(2-(4-((tert-butoxycarbonyl)oxy)but-2-en-1-yl)-5-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-2,2-bis(ethylthio)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction« Older EntriesNext Entries »
Spirocyclization, substituted (Z)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted 1-methyl-3-methyleneindolin-2-one, substituted (3R,3’R,5’S)-1”-methyl-5′-(trifluoromethyl)dispiro[indoline-3,2′-pyrrolidine-3′,3”-indoline]-2,2”-dione, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[[(1R)-1-phenylethyl]amino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeSpirocyclization
Spirocyclization, substituted (E)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, substituted (E)-nitroethene, substituted (3R,3’R,5’R)-3′-nitro-5′-(trifluoromethyl)spiro[indoline-3,2′-pyrrolidin]-2-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonidine DerivativeSpirocyclization
Hydrophosphonylation, 1-benzyl-3-iminoindolin-2-one, phosphonic acid ester, (R)-(3-amino-1-benzyl-2-oxoindolin-3-yl)phosphonic acid ester, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(4-methoxyphenyl)amino]-3-cyclobutene-1,2-dione, Cinchonidine DerivativeHydrophosphonylation
Aza-Michael Addition, (E)-3-(1-methylindolin-2-yl)-1-phenylprop-2-en-1-one, 4-phenyl-1-(phenylsulfonyl)-1H-1,2,3-triazole, 2-((1R)-9-methyl-4-phenyl-2-(phenylsulfonyl)-2,4a,9,9a-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-1-phenylethan-1-one, rhodium(II) acetate, 3-[(8α,9S)-cinchonan-9-ylamino]-4-[(phenylmethyl)amino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeAza-Michael, Michael Addition
[4+2] Annulation, substituted benzo[e][1,2,3]oxathiazine 2,2-dioxide, substituted (E)-pent-2-en-1-one, 1,3‐oxazinanes, hexahydropyrimidines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine Derivative[4+2] Annulation, Cyclization, Further Cyclizations
Desymmetrization, tert-butyl 7-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 1-(2-(tert-butyl)phenyl)-1H-pyrrole-2,5-dione, tert-butyl (R)-3-((S)-1-(2-(tert-butyl)phenyl)-2,5-dioxopyrrolidin-3-yl)-7-fluoro-2-oxo-3-phenylindoline-1-carboxylate, 3-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeAtropisomer synthesis, Desymmetrization
Spirocyclization, N-substituted (Z)-3-((2,2,2-trifluoroethyl)imino)indolin-2-one, Aryl substituted alkenes, substituted (3S,5’S)-5′-(trifluoromethyl)spiro[indoline-3,2′-pyrrolidin]-2-one, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeSpirocyclization
Cascade reaction, substituted 2-mercaptobenzaldehyde, substituted 1-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)prop-2-en-1-one, substituted (2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)((3S,4R)-4-hydroxythiochroman-3-yl)methanone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeCascade reaction
Cascade reaction, substituted (E)-3-trifluoromethyl-3-(1H-indol-3-yl)-1-phenylprop-2-en-1-one, substituted 2-mercaptobenzaldehyde, substituted ((2R,3S,4R)-4-hydroxy-2-((S)-indolin-3-yl)-2-(trifluoromethyl)thiochroman-3-yl)(phenyl)methanone, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[(8α,9S)-cinchonan-9-ylamino]-3-Cyclobutene-1,2-dione, Cinchonidine DerivativeCascade reaction
Pictet-Spengler Reaction, (E)-tert-butyl (4-((2-(4-methoxy-1H-indol-3-yl)ethyl)amino)but-2-en-1-yl) carbonate, methyl 2,2-bis(ethylthio)-5-oxopentanoate, methyl (S,E)-4-(2-(4-((tert-butoxycarbonyl)oxy)but-2-en-1-yl)-5-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-2,2-bis(ethylthio)butanoate, N-[3,5-Bis(trifluoromethyl)phenyl]- N′-(8α,9S)-cinchonan-9-ylthiourea, Cinchonidine DerivativeCyclization, Further Cyclizations, Pictet-Spengler Reaction
