Spirocyclization, substituted ethyl (E)-3-((2-oxoindolin-3-yl)oxy)acrylate, substituted 4-methyleneisoxazol-5(4H)-one, isoxazolone-spirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Michael Addition, acetylacetone, (E)-(2-nitrovinyl)benzene, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Vinylogous Mannich reaction, 2‐ethylidene-1,3‐indandiones, isatin N‐Boc ketimines, tert-butyl (S)-(1-benzyl-3-(2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)-2-phenylethyl)-5-methoxy-2-oxoindolin-3-yl)carbamate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich intramolecular Cyclization, methyl (E)-N-(2-((2-hydroxynaphthalen-1-yl)ethynyl)phenyl)isobutyrimidate, N-Bromsuccinimid, 1-bromopyrrolidine-2,5-dione–(8S)-14-bromo-8-isopropyl-8-methoxy-14,14a-dihydro-8H-naphtho[1′,2′:5,6][1,3]oxazino[3,4-a]indole, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]- 4-(trifluoromethyl)benzamide, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization Atropisomer Synthesis, substituted 1-ethynylnaphthalen-2-ol, substituted sulfinic acid sodium salt, sulfone-containing styrenes, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis Kinetic Resolution, racemic intermediates, 3‐Arylpyrroles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis, Kinetic resolution, Resolution Atropisomer Synthesis, nitroallyl alcanes, tert-butyl 2-isocyanoacetate, biaryls, silver oxide, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis Dynamic kinetic Resolution, biaryl lactones, alcohols, 2′-hydroxy-[1,1′-biphenyl]-2-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis, Dynamic Kinetic Resolution, Resolution Cyclization, substituted 1,1′-((1,8-diphenylnaphthalene-2,7-diyl)bis(ethyne-2,1-diyl))bis(naphthalen-2-ol), substituted 1,1′-(hexahelicene-1,8-diyl)bis(naphthalen-2-ol), 3,4-Bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization Atropisomer Synthesis, alkynyl ketones, isocyanoacetates, ethyl 3-(2-methoxynaphthalen-1-yl)-4-((4-methoxyphenoxy)methyl)-1H-pyrrole-2-carboxylate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis« Older EntriesNext Entries »
Spirocyclization, substituted ethyl (E)-3-((2-oxoindolin-3-yl)oxy)acrylate, substituted 4-methyleneisoxazol-5(4H)-one, isoxazolone-spirooxindoles, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Michael Addition, acetylacetone, (E)-(2-nitrovinyl)benzene, (S)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Vinylogous Mannich reaction, 2‐ethylidene-1,3‐indandiones, isatin N‐Boc ketimines, tert-butyl (S)-(1-benzyl-3-(2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)-2-phenylethyl)-5-methoxy-2-oxoindolin-3-yl)carbamate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich
intramolecular Cyclization, methyl (E)-N-(2-((2-hydroxynaphthalen-1-yl)ethynyl)phenyl)isobutyrimidate, N-Bromsuccinimid, 1-bromopyrrolidine-2,5-dione–(8S)-14-bromo-8-isopropyl-8-methoxy-14,14a-dihydro-8H-naphtho[1′,2′:5,6][1,3]oxazino[3,4-a]indole, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]- 4-(trifluoromethyl)benzamide, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
Atropisomer Synthesis, substituted 1-ethynylnaphthalen-2-ol, substituted sulfinic acid sodium salt, sulfone-containing styrenes, L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis
Kinetic Resolution, racemic intermediates, 3‐Arylpyrroles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis, Kinetic resolution, Resolution
Atropisomer Synthesis, nitroallyl alcanes, tert-butyl 2-isocyanoacetate, biaryls, silver oxide, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis
Dynamic kinetic Resolution, biaryl lactones, alcohols, 2′-hydroxy-[1,1′-biphenyl]-2-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis, Dynamic Kinetic Resolution, Resolution
Cyclization, substituted 1,1′-((1,8-diphenylnaphthalene-2,7-diyl)bis(ethyne-2,1-diyl))bis(naphthalen-2-ol), substituted 1,1′-(hexahelicene-1,8-diyl)bis(naphthalen-2-ol), 3,4-Bis[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-cyclobutene-1,2-dione, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
Atropisomer Synthesis, alkynyl ketones, isocyanoacetates, ethyl 3-(2-methoxynaphthalen-1-yl)-4-((4-methoxyphenoxy)methyl)-1H-pyrrole-2-carboxylate, 2-(diphenylphosphino)-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-benzamide, Quinine DerivativeAtropisomer synthesis
