Michael Addition, nitrostyrenes, α-alkylidene succinimides, substituted tert-butyl (R)-3-methylene-4-(2-nitroethyl)-2,5-dioxopyrrolidine-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Amination, 1-cyclohexenylaldehyde, di-tert-butyl azodicarboxylate, 1,2-Bis(1,1-dimethylethyl) 1-[(1S)-1-formyl-2-cyclohexen-1-yl]-1,2-hydrazinedicarboxylate, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeAmination Sulfonylation, (2E)-1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-buten-1-one, 3,5-Diethyl 4-cyclohexyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, DABCO-bis(sulfur dioxide), (3S)-3-(cyclohexylsulfonyl)-1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-butanone, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Sulfonylation Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH) Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization Michael Addition, (E)-(2-nitrovinyl)benzene, S,S-diphenyl propanebis(thioate), S,S-diphenyl 2-(2-nitro-1-phenylethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Cyclization, (2E,2’E)-3,3′-(1,2-phenylene)bis(1-(4-methoxyphenyl)prop-2-en-1-one), hydrazine hydrate, pyrazolines, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Cyclization, substituted phenylaminomaleate, substituted 2-methylenemalononitrile, chiral 1, 4-dihydropyridine derivatives, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Michael Addition, α-aryl isocyanoacetates, β-trifluoromethylated enones, substituted (3S)-2-isocyano-5-oxo-3-(trifluoromethyl)pentanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition Vinylogous Aldol, aldehydes, 3,4,5-trisubstituted furan-2(3H)-one, substituted 5-(hydroxymethyl)furan-2(5H)-one, N-[(2S)-2-[[2-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3-phenylpropyl]-1,1,2,2,3,3,4,4,4-nonafluoro-1-Butanesulfonamide, Dihydroquinine DerivativeAldol, Vinylogous Aldol« Older EntriesNext Entries »
Michael Addition, nitrostyrenes, α-alkylidene succinimides, substituted tert-butyl (R)-3-methylene-4-(2-nitroethyl)-2,5-dioxopyrrolidine-1-carboxylate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Amination, 1-cyclohexenylaldehyde, di-tert-butyl azodicarboxylate, 1,2-Bis(1,1-dimethylethyl) 1-[(1S)-1-formyl-2-cyclohexen-1-yl]-1,2-hydrazinedicarboxylate, (8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-amine, Dihydroquinine DerivativeAmination
Sulfonylation, (2E)-1-(3,5-Dimethyl-1H-pyrazol-1-yl)-2-buten-1-one, 3,5-Diethyl 4-cyclohexyl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, DABCO-bis(sulfur dioxide), (3S)-3-(cyclohexylsulfonyl)-1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-butanone, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeFurther reactions, Sulfonylation
Aza-Morita-Baylis-Hillman, cyclic ketimines, α,β-unsaturated γ-butyrolactam, substituted tert-butyl (R)-2-oxo-3-(3-oxo-2-phenylindolin-2-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMorita-Baylis-Hillman (MBH)
Cyclization, methyl (E)-2-(((2-hydroxyphenyl)(phenyl)methylene)amino)-2-(4-(trifluoromethyl)phenyl)acetate, methyl (S)-4-phenyl-2-(4-(trifluoromethyl)benzyl)-2H-benzo[e][1,3]oxazine-2-carboxylate, cobalt(II) tetrafluoroborate, 2-((E)-(((S)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl)imino)methyl)phenol, Dihydroquinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
Michael Addition, (E)-(2-nitrovinyl)benzene, S,S-diphenyl propanebis(thioate), S,S-diphenyl 2-(2-nitro-1-phenylethyl)propanebis(thioate), 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Cyclization, (2E,2’E)-3,3′-(1,2-phenylene)bis(1-(4-methoxyphenyl)prop-2-en-1-one), hydrazine hydrate, pyrazolines, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Cyclization, substituted phenylaminomaleate, substituted 2-methylenemalononitrile, chiral 1, 4-dihydropyridine derivatives, (8α,9R)-(8′′α,9′′R)-9,9′′-[(2,5-Diphenyl-4,6-pyrimidinediyl)bis(oxy)]bis[10,11-dihydro-6′-methoxycinchonan], Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Michael Addition, α-aryl isocyanoacetates, β-trifluoromethylated enones, substituted (3S)-2-isocyano-5-oxo-3-(trifluoromethyl)pentanoate, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4- [[(8α,9S)-10,11-dihydro-6′-methoxycinchonan- 9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael, Michael Addition
Vinylogous Aldol, aldehydes, 3,4,5-trisubstituted furan-2(3H)-one, substituted 5-(hydroxymethyl)furan-2(5H)-one, N-[(2S)-2-[[2-[[(8α,9S)-10,11-Dihydro-6′-methoxycinchonan-9-yl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-3-phenylpropyl]-1,1,2,2,3,3,4,4,4-nonafluoro-1-Butanesulfonamide, Dihydroquinine DerivativeAldol, Vinylogous Aldol
