Spirocyclization, polycyclic naphthols, polycyclic tetralones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Oxa-Michael Addition, Spirocyclization Michael Addition, nitroalkenes, dimethyl malonate, substituted dimethyl 2-(2-nitroethyl)malonate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition Cascade Reaction, substituted ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, thiols, aldehydes, primary amines, thiolated spiro-γ-lactam oxindoles, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]- N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCascade reaction Cascade Reaction, 1,12-diphenyldodeca-2,4,6,8,10-pentaene-1,12-dione, hydrazine hydrate, 1-phenyl-2-((3aR,8R)-2-phenyl-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindol-8-yl)ethan-1-one, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction Cyclopropanation, conjugated cyanosulfones, dimethyl 2-bromomalonate, 3-substituted dimethyl (2S,3R)-2-cyano-2-(phenylsulfonyl)cyclopropane-1,1-dicarboxylate, (8α,9R)-10,11-dihydro-9-(4-pentenoate)cinchonan-6′,9-diol, Dihydrocupreine DerivativeCyclopropanation Amination, Diethyl azodicarboxylate, ethyl 2-cyano-2-phenylacetate, 1,2-Diethyl 1-(1-cyano-2-ethoxy-2-oxo-1-phenylethyl)-1,2-hydrazinedicarboxylate, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine Derivativealpha-Amination, Amination Amination, Diethyl azodicarboxylate, Methyl 2-oxocyclopentanecarboxylate, 1,2-Diethyl 1-[(1S)-1-(methoxycarbonyl)-2-oxocyclopentyl]-1,2-hydrazinedicarboxylate, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine Derivativealpha-Amination, Amination Michael Addition, 2-hydroxy-1,4-naphthoquinone, nitroalkenes, substituted 2-hydroxy-3-(2-nitroethyl)naphthalene-1,4-dione, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Michael Addition, nitroalkenes, 1,3-dicarbonyl compounds, nitroalkanes, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition Resolution, racemic 7′-hydroxy-2′,3′-dihydrospiro[chromane-4,1′-inden]-2-one, (R)-7′-hydroxy-2′,3′-dihydrospiro[chromane-4,1′-inden]-2-one, (8α,9R)-9-hydroxy-1-(phenylmethyl)-Cinchonanium chloride, Cinchonidine DerivativeResolution« Older EntriesNext Entries »
Spirocyclization, polycyclic naphthols, polycyclic tetralones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeMichael Addition, Oxa-Michael Addition, Spirocyclization
Michael Addition, nitroalkenes, dimethyl malonate, substituted dimethyl 2-(2-nitroethyl)malonate, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxy-cinchonan-9-yl]-Thiourea, Dihydroquinine DerivativeMichael, Michael Addition
Cascade Reaction, substituted ethyl (E)-2-(2-oxoindolin-3-ylidene)acetate, thiols, aldehydes, primary amines, thiolated spiro-γ-lactam oxindoles, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]- N′-[4-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluorooctyl)phenyl]-thiourea, Dihydroquinine DerivativeCascade reaction
Cascade Reaction, 1,12-diphenyldodeca-2,4,6,8,10-pentaene-1,12-dione, hydrazine hydrate, 1-phenyl-2-((3aR,8R)-2-phenyl-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindol-8-yl)ethan-1-one, 3-[[(9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[(1,1-dimethylethyl)amino]-3-Cyclobutene-1,2-dione, Dihydroquinine DerivativeCascade reaction
Cyclopropanation, conjugated cyanosulfones, dimethyl 2-bromomalonate, 3-substituted dimethyl (2S,3R)-2-cyano-2-(phenylsulfonyl)cyclopropane-1,1-dicarboxylate, (8α,9R)-10,11-dihydro-9-(4-pentenoate)cinchonan-6′,9-diol, Dihydrocupreine DerivativeCyclopropanation
Amination, Diethyl azodicarboxylate, ethyl 2-cyano-2-phenylacetate, 1,2-Diethyl 1-(1-cyano-2-ethoxy-2-oxo-1-phenylethyl)-1,2-hydrazinedicarboxylate, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine Derivativealpha-Amination, Amination
Amination, Diethyl azodicarboxylate, Methyl 2-oxocyclopentanecarboxylate, 1,2-Diethyl 1-[(1S)-1-(methoxycarbonyl)-2-oxocyclopentyl]-1,2-hydrazinedicarboxylate, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine Derivativealpha-Amination, Amination
Michael Addition, 2-hydroxy-1,4-naphthoquinone, nitroalkenes, substituted 2-hydroxy-3-(2-nitroethyl)naphthalene-1,4-dione, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Michael Addition, nitroalkenes, 1,3-dicarbonyl compounds, nitroalkanes, 3-[[[(1S)-2,2′-dihydroxy[1,1′-binaphthalen]-3-yl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeMichael, Michael Addition
Resolution, racemic 7′-hydroxy-2′,3′-dihydrospiro[chromane-4,1′-inden]-2-one, (R)-7′-hydroxy-2′,3′-dihydrospiro[chromane-4,1′-inden]-2-one, (8α,9R)-9-hydroxy-1-(phenylmethyl)-Cinchonanium chloride, Cinchonidine DerivativeResolution
