Amination, benzyl 2-benzylhydrazine-1-carboxylate, α, β‐unsaturated ketones, benzyl 2-benzyl-2-(2-oxoheptan-4-yl)hydrazine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination Mannich reaction, 6,8-dibromobenzo[e][1,2,3]oxathiazine 2,2-dioxide, ethyl 3-oxobutanoate, ethyl (S)-4-(6,8-dibromo-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-oxobutanoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMannich, Mannich Strecker reaction, 1-benzyl-7-fluoro-3-iminoindolin-2-one, trimethylsilanecarbonitrile, (S)-3-amino-1-benzyl-7-fluoro-2-oxoindoline-3-carbonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker Hetero Diels-Alder, 1-((2′-bromo-[1,1′-biphenyl]-2-yl)ethynyl)naphthalen-2-ol, N-Bromosuccinimide, (7aR,11aS,16S,16aS)-11,16-dibromo-16,16a-dihydro-7aH-benzo[a]indeno[1,2-l]xanthene, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-4-(trifluoromethyl)benzamide, Quinine DerivativeCycloaddition, Diels-Alder reaction Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation Friedel-Crafts Alkylation, 1-bromo1-nitroalkenes, 1H-indol-4-ol, 3-substituted (R)-2-nitro-3,6-dihydro-2H-furo[2,3-e]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation Mannich reaction, substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines, trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives, 3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Mannich, Mannich Mannich reaction, 2-pyridyl N-oxide acetates, N-Boc imines, α- and β-functionalized 2-substituted pyridines, Phenylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich Mannich reaction, imines, sulfonylacetonitriles, β-amino nitriles, 9H-Fluoren-9-ylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich Sulfa-Michael Addition, aromatic thiols, nitroalkenes, 2-nitro-1-arylethyl sulfides, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition« Older EntriesNext Entries »
Amination, benzyl 2-benzylhydrazine-1-carboxylate, α, β‐unsaturated ketones, benzyl 2-benzyl-2-(2-oxoheptan-4-yl)hydrazine-1-carboxylate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAmination
Mannich reaction, 6,8-dibromobenzo[e][1,2,3]oxathiazine 2,2-dioxide, ethyl 3-oxobutanoate, ethyl (S)-4-(6,8-dibromo-2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-3-oxobutanoate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMannich, Mannich
Strecker reaction, 1-benzyl-7-fluoro-3-iminoindolin-2-one, trimethylsilanecarbonitrile, (S)-3-amino-1-benzyl-7-fluoro-2-oxoindoline-3-carbonitrile, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeStrecker
Hetero Diels-Alder, 1-((2′-bromo-[1,1′-biphenyl]-2-yl)ethynyl)naphthalen-2-ol, N-Bromosuccinimide, (7aR,11aS,16S,16aS)-11,16-dibromo-16,16a-dihydro-7aH-benzo[a]indeno[1,2-l]xanthene, N-[(8α,9S)-6′-Methoxycinchonan-9-yl]-4-(trifluoromethyl)benzamide, Quinine DerivativeCycloaddition, Diels-Alder reaction
Friedel-Crafts Alkylation, indoles, nitroalkenes, 3-(2-nitroethyl)-indoles, 3-[(1,1-dimethylethyl)amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation
Friedel-Crafts Alkylation, 1-bromo1-nitroalkenes, 1H-indol-4-ol, 3-substituted (R)-2-nitro-3,6-dihydro-2H-furo[2,3-e]indole, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeFriedel-Crafts, Friedel-Crafts alkylation
Mannich reaction, substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines, trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives, 3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Mannich, Mannich
Mannich reaction, 2-pyridyl N-oxide acetates, N-Boc imines, α- and β-functionalized 2-substituted pyridines, Phenylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich
Mannich reaction, imines, sulfonylacetonitriles, β-amino nitriles, 9H-Fluoren-9-ylmethyl N-[(1S)-1-[[[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]carbonyl]amino]-2,2-dimethylpropyl]carbamate, Quinine DerivativeMannich, Mannich
Sulfa-Michael Addition, aromatic thiols, nitroalkenes, 2-nitro-1-arylethyl sulfides, (2S)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-[(8α,9S)-6′-methoxycinchonan-9-yl]-3,3-dimethylbutanamide, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
