Desymmetrization, 4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol, (R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization Aza-Mannich Addition, 2-(ethylthio)thiazol-5(4H)-ones, substituted 4-methyl-N-methylenebenzenesulfonamide, modified chiral 2-(ethylthio)-thiazolone derivatives, (8α,9R)-6′-Methoxy-9-[(trimethylsilyl)oxy]cinchonan, Quinine DerivativeAza-Mannich, Mannich Bromolactonization, (Z)-2-(pent-2-en-4-yn-1-yloxy)benzoic acids, N-Bromosuccinimide, (S)-3-(4-bromo-3l5-buta-2,3-dien-1-yl)-2,3-dihydro-5H-benzo[e][1,4]dioxepin-5-ones, N-[[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]carbonyl]-4-methylbenzenesulfonamide, Quinine DerivativeBromination, Lactonization Cascade reaction, (E)-1-nitrohex-1-ene, (E)-7-oxo-7-phenylhept-5-enal, (1S,2S,3S,4S)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexane-1-carbaldehyde, D-Proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction Aza-Henry (Nitro-Mannich), imines, nitroethane, β-nitro amines, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Sulfenylation, 5-methyl-2-(naphthalen-1-yl)oxazol-4(5H)-one, 1-((2-bromophenyl)thio)pyrrolidine-2,5-dione, (S)-5-((2-bromophenyl)thio)-5-methyl-2-(naphthalen-1-yl)oxazol-4(5H)-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSulfenylation Fluorination, tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylates, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, tert-butyl (S)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylates, (1S,2S,4S,5R)-2-((S)-((2-((3,5-bis(trifluoromethyl)phenyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)(6-methoxyquinolin-4-yl)methyl)-1-(3,5-di-tert-butylbenzyl)-5-vinylquinuclidin-1-ium bromide, Quinine DerivativeFluorination, Fluorination of beta-ketoester Cyclization, 5-alkenyl thiazolones, β,γ-unsaturated carbonyl compounds, highly functionalized pyranthiazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cycloaddition, Diels-Alder reaction Sulfa-Michael Addition, trisubstituted nitroalkenes, thioacids, 1,2-nitrothioacetates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition Biginelli reaction, α,β-unsaturated aldehydes, thiourea, β-ketoesters, 3,4-dihydro-pyrimidin-2-(1H)-thiones, trans-4,5-methano-L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions« Older EntriesNext Entries »
Desymmetrization, 4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione, methanol, (R)-3-(4-fluorophenyl)-5-methoxy-5-oxopentanoic acid, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization
Aza-Mannich Addition, 2-(ethylthio)thiazol-5(4H)-ones, substituted 4-methyl-N-methylenebenzenesulfonamide, modified chiral 2-(ethylthio)-thiazolone derivatives, (8α,9R)-6′-Methoxy-9-[(trimethylsilyl)oxy]cinchonan, Quinine DerivativeAza-Mannich, Mannich
Bromolactonization, (Z)-2-(pent-2-en-4-yn-1-yloxy)benzoic acids, N-Bromosuccinimide, (S)-3-(4-bromo-3l5-buta-2,3-dien-1-yl)-2,3-dihydro-5H-benzo[e][1,4]dioxepin-5-ones, N-[[[(8α,9S)-6′-Methoxycinchonan-9-yl]amino]carbonyl]-4-methylbenzenesulfonamide, Quinine DerivativeBromination, Lactonization
Cascade reaction, (E)-1-nitrohex-1-ene, (E)-7-oxo-7-phenylhept-5-enal, (1S,2S,3S,4S)-2-butyl-3-nitro-4-(2-oxo-2-phenylethyl)cyclohexane-1-carbaldehyde, D-Proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCascade reaction
Aza-Henry (Nitro-Mannich), imines, nitroethane, β-nitro amines, N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Sulfenylation, 5-methyl-2-(naphthalen-1-yl)oxazol-4(5H)-one, 1-((2-bromophenyl)thio)pyrrolidine-2,5-dione, (S)-5-((2-bromophenyl)thio)-5-methyl-2-(naphthalen-1-yl)oxazol-4(5H)-one, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeSulfenylation
Fluorination, tert-butyl 1-oxo-2,3-dihydro-1H-indene-2-carboxylates, N-fluoro-N-(phenylsulfonyl)benzenesulfonamide, tert-butyl (S)-2-fluoro-1-oxo-2,3-dihydro-1H-indene-2-carboxylates, (1S,2S,4S,5R)-2-((S)-((2-((3,5-bis(trifluoromethyl)phenyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)(6-methoxyquinolin-4-yl)methyl)-1-(3,5-di-tert-butylbenzyl)-5-vinylquinuclidin-1-ium bromide, Quinine DerivativeFluorination, Fluorination of beta-ketoester
Cyclization, 5-alkenyl thiazolones, β,γ-unsaturated carbonyl compounds, highly functionalized pyranthiazoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cycloaddition, Diels-Alder reaction
Sulfa-Michael Addition, trisubstituted nitroalkenes, thioacids, 1,2-nitrothioacetates, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael Addition, Sulfa-Michael, Sulfa-Michael Addition
Biginelli reaction, α,β-unsaturated aldehydes, thiourea, β-ketoesters, 3,4-dihydro-pyrimidin-2-(1H)-thiones, trans-4,5-methano-L-proline, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeBiginelli reaction, Further reactions
