Spirocyclization, oxindoles, N-protected (E)-3-benzylidenepyrrolidine-2,5-dione, N-protected ethyl (3aS,4R,5S,6R,6aS)-1,2′,3-trioxo-6-phenyl-4-(trifluoromethyl)-2,3,3a,4,6,6a-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,3′-indoline]-4-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization Aldol reaction, isatins, 2,2‐difluoro‐1,3‐diketones, substituted (S)-3-(1,1-difluoro-2-oxo-2-substituted-ethyl)-3-hydroxyindolin-2-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAldol, Aldol Cyclization, enoates, unsaturated ketones, methyl (2R,3R,4S)-4-(4-methoxyphenyl)-2-(2-oxo-2-phenylethyl)-3-phenyl-3,4-dihydro-2H-pyran-6-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Cycloaddition, Diels-Alder reaction, Further Cyclizations Desymmetrization, substituted 2,4-dihydro-3H-pyrazol-3-one, cyclopentenediones, substituted 4-(5-hydroxy-1H-pyrazol-4-yl)cyclopent-4-ene-1,3-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization Atropisomer Synthesis, 1,1′-(1,2-phenylenebis(ethyne-2,1-diyl))bis(3-methoxynaphthalen-2-ol), heterobiaryls, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[4+2]-Cycloaddition, Atropisomer synthesis, Cycloaddition Atropisomer Synthesis, ortho‐alkynylanilines, (S)-1-(1-(tert-butyl)indolin-2-yl)naphthalen-2-ol, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis Michael Addition, cyclohexenone, thiomalonates, S,S-dibenzyl (S)-2-(3-oxocyclohexyl)propanebis(thioate), 2-fluorobenzoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition Michael Addition, 3-benzyl-3-hydroxy-1-(4-nitrophenyl)-4-phenylbutan-2-one, (E)-(2-nitrovinyl)benzene, (4R,5S)-2-benzyl-2-hydroxy-6-nitro-4-(4-nitrophenyl)-1,5-diphenylhexan-3-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition Mannich reaction, isatin N-Boc ketimines, α-substituted monothiomalonates, 3,3-disubstituted oxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich Spirocyclization, 4-isothiocyanato-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one, oxindoles, spirooxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization« Older EntriesNext Entries »
Spirocyclization, oxindoles, N-protected (E)-3-benzylidenepyrrolidine-2,5-dione, N-protected ethyl (3aS,4R,5S,6R,6aS)-1,2′,3-trioxo-6-phenyl-4-(trifluoromethyl)-2,3,3a,4,6,6a-hexahydro-1H-spiro[cyclopenta[c]pyrrole-5,3′-indoline]-4-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition, Spirocyclization
Aldol reaction, isatins, 2,2‐difluoro‐1,3‐diketones, substituted (S)-3-(1,1-difluoro-2-oxo-2-substituted-ethyl)-3-hydroxyindolin-2-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAldol, Aldol
Cyclization, enoates, unsaturated ketones, methyl (2R,3R,4S)-4-(4-methoxyphenyl)-2-(2-oxo-2-phenylethyl)-3-phenyl-3,4-dihydro-2H-pyran-6-carboxylate, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeCyclization, Cyclization, Cycloaddition, Diels-Alder reaction, Further Cyclizations
Desymmetrization, substituted 2,4-dihydro-3H-pyrazol-3-one, cyclopentenediones, substituted 4-(5-hydroxy-1H-pyrazol-4-yl)cyclopent-4-ene-1,3-dione, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeDesymmetrization
Atropisomer Synthesis, 1,1′-(1,2-phenylenebis(ethyne-2,1-diyl))bis(3-methoxynaphthalen-2-ol), heterobiaryls, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine Derivative[4+2]-Cycloaddition, Atropisomer synthesis, Cycloaddition
Atropisomer Synthesis, ortho‐alkynylanilines, (S)-1-(1-(tert-butyl)indolin-2-yl)naphthalen-2-ol, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeAtropisomer synthesis
Michael Addition, cyclohexenone, thiomalonates, S,S-dibenzyl (S)-2-(3-oxocyclohexyl)propanebis(thioate), 2-fluorobenzoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition
Michael Addition, 3-benzyl-3-hydroxy-1-(4-nitrophenyl)-4-phenylbutan-2-one, (E)-(2-nitrovinyl)benzene, (4R,5S)-2-benzyl-2-hydroxy-6-nitro-4-(4-nitrophenyl)-1,5-diphenylhexan-3-one, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMichael, Michael Addition
Mannich reaction, isatin N-Boc ketimines, α-substituted monothiomalonates, 3,3-disubstituted oxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeMannich, Mannich
Spirocyclization, 4-isothiocyanato-2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one, oxindoles, spirooxindoles, N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, Quinine DerivativeSpirocyclization
