Aza-Michael Addition, α,β‐unsaturated ketones, N‐neterocycles, substituted N‐heterocycles, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael Addition Nucleophilic Substitution, 2-((4-bromophenyl)(hydroxy)methyl)cyclopent-2-en-1-one, 1H-indole, (S,E)-2-(4-bromobenzylidene)-4-(1H-indol-3-yl)cyclopentan-1-one, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeFurther reactions, Nucleophilic Substitution Michael Addition, α,β-unsaturated ketones, 1-bromonitroalkanes, substituted 4-bromo-4-nitrobutanoyl, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition Spirocyclization, 2‐Isothiocyanato‐1‐indanones, 2‐Arylidene‐1,3‐indanediones, substituted (S)-5′-thioxodispiro[indene-2,2′-pyrrolidine-4′,2”-indene]-1,1”,3”(3H)-trione, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine Derivative[3+2] Annulation, Cyclization, Further Cyclizations, Spirocyclization Cyclization, 2-substituted 2-(5-chloro-2-isocyanophenyl)acetonitrile, 3-substituted 5-chloro-3H-indole-3-carbonitrile, (8α,9S)-6′-methoxy-9-[[[(4-nitrophenyl)amino]carbonyl]amino]-1-(phenylmethyl)-cinchonanium bromide, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization Aza-Henry (Nitro-Mannich), substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, substituted tert-butyl (2-nitroethyl)carbamate, (9S)-9-[[[[(1R)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinidine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Aza-Henry (Nitro-Mannich), substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, substituted tert-butyl (2-nitroethyl)carbamate, (8α,9S)-9-[[[[(1S)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Aza-Henry (Nitro-Mannich), substituted N-((6-methylpyridin-2-yl)sulfonyl)acetimidoyl, nitromethane, N-(2-substituted-1-nitropropan-2-yl)-6-methylpyridine-2-sulfonamide, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-6′-methoxy-1-[(2-methoxyphenyl)methyl]-cinchonanium bromide, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich Alkylation, 2‐oxindoles, 1-bromo-3-methylbut-2-ene, 3,3-disubstituted 2-oxindoles, (8α,9S)-2′-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine DerivativeAlkylation, alpha-Alkylation Atropisomer synthesis, diaryl ethers, nitromethane, diaryl ethers, (8α,9S)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine DerivativeAlkylation, Alkylation, Atropisomer synthesis« Older EntriesNext Entries »
Aza-Michael Addition, α,β‐unsaturated ketones, N‐neterocycles, substituted N‐heterocycles, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael Addition
Nucleophilic Substitution, 2-((4-bromophenyl)(hydroxy)methyl)cyclopent-2-en-1-one, 1H-indole, (S,E)-2-(4-bromobenzylidene)-4-(1H-indol-3-yl)cyclopentan-1-one, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeFurther reactions, Nucleophilic Substitution
Michael Addition, α,β-unsaturated ketones, 1-bromonitroalkanes, substituted 4-bromo-4-nitrobutanoyl, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeMichael, Michael Addition
Spirocyclization, 2‐Isothiocyanato‐1‐indanones, 2‐Arylidene‐1,3‐indanediones, substituted (S)-5′-thioxodispiro[indene-2,2′-pyrrolidine-4′,2”-indene]-1,1”,3”(3H)-trione, 3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, Quinine Derivative[3+2] Annulation, Cyclization, Further Cyclizations, Spirocyclization
Cyclization, 2-substituted 2-(5-chloro-2-isocyanophenyl)acetonitrile, 3-substituted 5-chloro-3H-indole-3-carbonitrile, (8α,9S)-6′-methoxy-9-[[[(4-nitrophenyl)amino]carbonyl]amino]-1-(phenylmethyl)-cinchonanium bromide, Quinine DerivativeCyclization, Further Cyclizations, Intramolecular cyclization
Aza-Henry (Nitro-Mannich), substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, substituted tert-butyl (2-nitroethyl)carbamate, (9S)-9-[[[[(1R)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinidine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Aza-Henry (Nitro-Mannich), substituted tert-butyl ((phenylsulfonyl)methyl)carbamate, nitroalkanes, substituted tert-butyl (2-nitroethyl)carbamate, (8α,9S)-9-[[[[(1S)-2-hydroxy-1-phenylethyl]amino]carbonyl]amino]-6′-methoxy-1-(phenylmethyl)-cinchonanium bromide, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Aza-Henry (Nitro-Mannich), substituted N-((6-methylpyridin-2-yl)sulfonyl)acetimidoyl, nitromethane, N-(2-substituted-1-nitropropan-2-yl)-6-methylpyridine-2-sulfonamide, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-6′-methoxy-1-[(2-methoxyphenyl)methyl]-cinchonanium bromide, Quinine DerivativeAza-Henry, Henry, Mannich, Nitro-Mannich
Alkylation, 2‐oxindoles, 1-bromo-3-methylbut-2-ene, 3,3-disubstituted 2-oxindoles, (8α,9S)-2′-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl]-1-[[3,5-bis(1,1-dimethylethyl)phenyl]methyl]-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine DerivativeAlkylation, alpha-Alkylation
Atropisomer synthesis, diaryl ethers, nitromethane, diaryl ethers, (8α,9S)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-6′-methoxy-cinchonanium bromide, Quinine DerivativeAlkylation, Alkylation, Atropisomer synthesis
