Spirocyclization Mannich – Boc-Deprotection – Aza-Michael, tert-butyl (Z)-(2-oxoindolin-3-ylidene)carbamate, ethyl (E)-4-(2-oxoindolin-3-yl)but-2-enoate, 3,3′-pyrrolidinyl-dispirooxindoles, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCascade reaction, Spirocyclization Cascade Aza-Michael-Aldol reaction, 2-(1H-pyrrol-2-yl)-2-oxoacetates, enones, chiral pyrrolizines, (8α,9S)-6′-(2,2-Dimethylpropoxy)cinchonan-9-amine, Quinine DerivativeCascade reaction, Cyclization Cascade Aza-Michael/Michael Addition, (E)-N-(2-(3-substituted-3-oxoprop-1-en-1-yl)phenyl)-4-methylbenzenesulfonamide, substituted (E)-3-(2-subsituted-2-oxoethylidene)indolin-2-one, spirooxindole tetrahydroquinolines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Spirocyclization Aza-Michael/Michael cascade, substituted-3-(methylene)indolin-2-ones, alpha,beta unsaturated amide esters, spiro-oxindole piperidin-2-one derivatives, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization Aza-Michael-Michael Addition, cyclohex-2-en-1-one, ethyl (E)-4-((benzyloxy)amino)-4-oxobut-2-enoate, ethyl 2-((3S,3aS,7aS)-1-(benzyloxy)-2,4-dioxooctahydro-1H-indol-3-yl)acetate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael, Michael Addition Aza-Michael Addition, tert-butyl (naphthalen-2-ylmethoxy)carbamate, cyclic enones, N-substituted tert-butyl (naphthalen-2-ylmethoxy)carbamate, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide, Quinine DerivativeAza-Michael, Michael Addition Aza-Michael Addition, halogenated 2‐hydroxypyridines, alpha,beta-unsaturated 1,4-dicarbonyl compounds, N‐substituted 2‐pyridones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine DerivativeAza-Michael, Michael Addition Aza-Michael Addition, (E)-chalcone, 1H-pyrazole, (R)-1,3-diphenyl-3-(1H-pyrazol-1-yl)propan-1-one, 1-hydroxy-2-naphthoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael Addition Aza-Michael Addition, 1H-pyrazole, (E)-1-phenylbut-2-en-1-one, (R)-1-phenyl-3-(1H-pyrazol-1-yl)butan-1-one, (8α,9S)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-(1-methylethoxy)-Cinchonanium bromide, Cupreine DerivativeAza-Michael, Michael Addition Aza-Michael Addition, 4-methyl-N-(2-((1E,4E)-3-oxo-5-phenylpenta-1,4-dien-1-yl)phenyl)benzenesulfonamide, (E)-(2-nitrovinyl)benzene, Hydrophenanthridines, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAza-Michael, Michael Addition« Older EntriesNext Entries »
Spirocyclization Mannich – Boc-Deprotection – Aza-Michael, tert-butyl (Z)-(2-oxoindolin-3-ylidene)carbamate, ethyl (E)-4-(2-oxoindolin-3-yl)but-2-enoate, 3,3′-pyrrolidinyl-dispirooxindoles, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCascade reaction, Spirocyclization
Cascade Aza-Michael-Aldol reaction, 2-(1H-pyrrol-2-yl)-2-oxoacetates, enones, chiral pyrrolizines, (8α,9S)-6′-(2,2-Dimethylpropoxy)cinchonan-9-amine, Quinine DerivativeCascade reaction, Cyclization
Cascade Aza-Michael/Michael Addition, (E)-N-(2-(3-substituted-3-oxoprop-1-en-1-yl)phenyl)-4-methylbenzenesulfonamide, substituted (E)-3-(2-subsituted-2-oxoethylidene)indolin-2-one, spirooxindole tetrahydroquinolines, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Spirocyclization Aza-Michael/Michael cascade, substituted-3-(methylene)indolin-2-ones, alpha,beta unsaturated amide esters, spiro-oxindole piperidin-2-one derivatives, 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione, Quinine DerivativeCascade reaction, Spirocyclization
Aza-Michael-Michael Addition, cyclohex-2-en-1-one, ethyl (E)-4-((benzyloxy)amino)-4-oxobut-2-enoate, ethyl 2-((3S,3aS,7aS)-1-(benzyloxy)-2,4-dioxooctahydro-1H-indol-3-yl)acetate, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael, Michael Addition
Aza-Michael Addition, tert-butyl (naphthalen-2-ylmethoxy)carbamate, cyclic enones, N-substituted tert-butyl (naphthalen-2-ylmethoxy)carbamate, (8α,9S)-9-[[[[3,5-bis(trifluoromethyl)phenyl]amino]carbonyl]amino]-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6′-methoxy-Cinchonanium bromide, Quinine DerivativeAza-Michael, Michael Addition
Aza-Michael Addition, halogenated 2‐hydroxypyridines, alpha,beta-unsaturated 1,4-dicarbonyl compounds, N‐substituted 2‐pyridones, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3-cyclobutene-1,2-dione, Cinchonine DerivativeAza-Michael, Michael Addition
Aza-Michael Addition, (E)-chalcone, 1H-pyrazole, (R)-1,3-diphenyl-3-(1H-pyrazol-1-yl)propan-1-one, 1-hydroxy-2-naphthoic acid, (8α,9S)-6′-Methoxycinchonan-9-amine, Quinine DerivativeAza-Michael, Michael Addition
Aza-Michael Addition, 1H-pyrazole, (E)-1-phenylbut-2-en-1-one, (R)-1-phenyl-3-(1H-pyrazol-1-yl)butan-1-one, (8α,9S)-1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-6′-(1-methylethoxy)-Cinchonanium bromide, Cupreine DerivativeAza-Michael, Michael Addition
Aza-Michael Addition, 4-methyl-N-(2-((1E,4E)-3-oxo-5-phenylpenta-1,4-dien-1-yl)phenyl)benzenesulfonamide, (E)-(2-nitrovinyl)benzene, Hydrophenanthridines, 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(9R)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione, Quinidine DerivativeAza-Michael, Michael Addition
