α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-1-[(1-oxido-2-pyridinyl)methyl]-9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (9S)-1-(9-anthracenylmethyl)-9-hydroxy-Cinchonanium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 4,4′-(bromomethylene)bis(fluorobenzene), tert-butyl (S)-2-((diphenylmethylene)amino)-3,3-bis(4-fluorophenyl)propanoate, (8α,9R)-1-(9-anthracenylmethyl)-9- (2-propenyloxy)-Cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 1-(bromomethyl)-2-nitrobenzene, tert-butyl (R)-2-((diphenylmethylene)amino)-3-(2-nitrophenyl)propanoate, (9S)-1-(9-anthracenylmethyl)-9-(2-propenyloxy)-Cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation Benzylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)- 1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromoprop-1-ene, tert-butyl (R)-2-((diphenylmethylene)amino)pent-4-enoate, (1S,2R,4S,5R)-1-((7-bromo-4-chloroquinazolin-2-yl)methyl)-2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation Cyclopropanation, (E)-N-(phenylmethylene)-glycine ethylester, trans-1,4-dibromo-2-butene, ethyl (1R,2S)-1-(((E)-benzylidene)amino)-2-vinylcyclopropane-1-carboxylate, (8α,9R)1-[[2,4-Bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonidine DerivativeCyclopropanation Desymmetrization, (3aR,4S,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione, methanol, (1S,2R,3S,4R)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, (1R,2S,3R,4S)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, Quinidine BaseDesymmetrization Bromolactonization/Desymmetrization, cyclohexadiene derivatives, N-bromosuccimide, bromolactones, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCyclization, Desymmetrization, Lactonization Desymmetrization, 4-phenyldihydro-2H-pyran-2,6(3H)-dione, azidotrimethylsilane, hydrochloric acid, intermediate: (R)-5-azido-5-oxo-3-phenylpentanoic acid, (R)-4-phenylpyrrolidin-2-one, Quinine DerivativeDesymmetrization« Older EntriesNext Entries »
α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-1-[(1-oxido-2-pyridinyl)methyl]-9-(2-propen-1-yloxy)-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (R)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (9S)-1-(9-anthracenylmethyl)-9-hydroxy-Cinchonanium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation
α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 4,4′-(bromomethylene)bis(fluorobenzene), tert-butyl (S)-2-((diphenylmethylene)amino)-3,3-bis(4-fluorophenyl)propanoate, (8α,9R)-1-(9-anthracenylmethyl)-9- (2-propenyloxy)-Cinchonanium bromide, Cinchonidine DerivativeAlkylation, alpha-Alkylation
α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 1-(bromomethyl)-2-nitrobenzene, tert-butyl (R)-2-((diphenylmethylene)amino)-3-(2-nitrophenyl)propanoate, (9S)-1-(9-anthracenylmethyl)-9-(2-propenyloxy)-Cinchonanium bromide, Cinchonine DerivativeAlkylation, alpha-Alkylation
Benzylation, tert-butyl 2-((diphenylmethylene)amino)acetate, benzylbromide, tert-butyl (S)-2-((diphenylmethylene)amino)-3-phenylpropanoate, (8α,9R)-10,11-dihydro-9-(2-propen-1-yloxy)- 1-[(2,3,4-trifluorophenyl)methyl]-Cinchonanium bromide, Dihydrocinchonidine DerivativeAlkylation, alpha-Alkylation
α-Alkylation, tert-butyl 2-((diphenylmethylene)amino)acetate, 3-bromoprop-1-ene, tert-butyl (R)-2-((diphenylmethylene)amino)pent-4-enoate, (1S,2R,4S,5R)-1-((7-bromo-4-chloroquinazolin-2-yl)methyl)-2-((S)-hydroxy(quinolin-4-yl)methyl)-5-vinylquinuclidin-1-ium chloride, Cinchonine DerivativeAlkylation, alpha-Alkylation
Cyclopropanation, (E)-N-(phenylmethylene)-glycine ethylester, trans-1,4-dibromo-2-butene, ethyl (1R,2S)-1-(((E)-benzylidene)amino)-2-vinylcyclopropane-1-carboxylate, (8α,9R)1-[[2,4-Bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-cinchonanium bromide, Cinchonidine DerivativeCyclopropanation
Desymmetrization, (3aR,4S,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1,3-dione, methanol, (1S,2R,3S,4R)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, (1R,2S,3R,4S)-3-(methoxycarbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, Quinidine BaseDesymmetrization
Bromolactonization/Desymmetrization, cyclohexadiene derivatives, N-bromosuccimide, bromolactones, 1,4-Bis(9-O-dihydroquinidinyl)phthalazine, Dihydroquinidine DerivativeCyclization, Desymmetrization, Lactonization
Desymmetrization, 4-phenyldihydro-2H-pyran-2,6(3H)-dione, azidotrimethylsilane, hydrochloric acid, intermediate: (R)-5-azido-5-oxo-3-phenylpentanoic acid, (R)-4-phenylpyrrolidin-2-one, Quinine DerivativeDesymmetrization
