Cyclization, 3-(benzhydrylamino)cyclohex-2-en-1-one, ethyl 3,3,3-trifluoro-2-oxopropanoate, (S)-1-benzhydryl-3-hydroxy-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations Domino Aldol Cyclization, 4-nitrobenzaldehyde, benzhydryl 2-cyanoacetate, benzhydryl (4R,5S)-5-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydroquinine DerivativeAldol, Aldol, Cyclization, Cyclization, Further Cyclizations [4+2] Annulation, substituted 2,6-di-tert-butyl-4-(2-hydroxybenzylidene)cyclohexa-2,5-dien-1-one, substituted 2-cyanoacetate, 3-substituted (4R)-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxochromane-3-carbonitrile, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydroquinine DerivativeAddition Steglich, Aldol, benzyl 2-(((benzyloxy)carbonyl)oxy)-3-methylindoline-1-carboxylate, 4-nitrobenzaldehyde, benzyl (R)-3-((S)-(((benzyloxy)carbonyl)oxy)(4-nitrophenyl)methyl)-3-methyl-2-oxoindoline-1-carboxylate, (8α,9R)-1-[(4,4′′-dimethoxy[1,1′:3′,1′′-terphenyl]-5′-yl)methyl]-6′-hydroxy-9-(phenylmethoxy)-cinchonanium inner salt, Cupreine DerivativeAldol, Aldol, Further reactions, Steglich rearrangement Mannich reaction, 3,5-disubstituted indolin-2-one, substituted (E)-N-tosylformimidoyl, N-((S)-substituted-((S)-3,5-disubstituted-2-oxoindolin-3-yl)methyl)-4-methylbenzenesulfonamide, (8α,9R)-9-(9-phenanthrenyloxy)-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich Sulfa-Michael Mannich cascade, thiols, 1,3 disubstituted (E)-prop-2-en-1-one, substituted (Z)-N-tosylformimidoyl, N-((1R,2R,3S)-2-(substituted-carbonyl)-1,3-disubstituted-3-(substitutedthio)propyl)-4-methylbenzenesulfonamide, (8α,9R)-1-[(2-nitrophenyl)methyl]-9-(2-propen-1-yloxy)-6′-(4-propylphenyl)-cinchonanium bromide, Cupreine DerivativeCascade reaction, Mannich, Mannich, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition Sulfa-Michael Henry, substituted 2-mercaptoquinoline-3-carbaldehyde, substituted (E)-nitroethene, substituted (2R,3S,4R)-2-substituted-3-nitro-3,4-dihydro-2H-thiopyrano[2,3-b]quinolin-4-ol, (8α,9R)-9-butoxy-cinchonan-6′-ol, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition 1,6-Conjugate Addition, substituted 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-ol, disubstituted (diazomethyl)phosphonate, substituted ((2S)-2-(3,5-di-tert-butyl-4-hydroxycyclohexa-2,5-dien-1-yl)-1-diazo-2-phenylethyl)phosphonate, 1-[[3,5-bis(1,1-dimethylethyl)-2,6-diethoxyphenyl]methyl]-9-hydroxy-6′-(2-naphthalenyl)-cinchonanium chloride, Cupreine DerivativeAddition Bromoaminocyclization, (E)-N-(5-substituted-pent-4-en-1-yl)-4-nitrobenzenesulfonamide, 1,3-Dibromo-5,5-Dimethylhydantoin, 2-substituted (2R,3S)-3-bromo-1-((4-nitrophenyl)sulfonyl)piperidine, (8α,9R)-9-[N-(2,4-dimethoxyphenyl)carbamothioate]-6′-(2,2-dimethylpropoxy)-cinchonan-9-ol, Cupreine DerivativeBromination, Cyclization, Further Cyclizations, Intramolecular cyclization Bromoaminocyclization, substituted 4-nitro-N-(pent-4-en-1-yl)benzenesulfonamide, N-Bromosuccinimide, 2-substituted 2-(bromomethyl)-1-((4-nitrophenyl)sulfonyl)pyrrolidine, (8α,9R)-9-[N-(2,6-diethoxyphenyl)carbamothioate]-6′-(3-methylbutoxy)-cinchonan-9-ol, Cupreine DerivativeBromination, Cyclization, Further Cyclizations, Intramolecular cyclization« Older EntriesNext Entries »
Cyclization, 3-(benzhydrylamino)cyclohex-2-en-1-one, ethyl 3,3,3-trifluoro-2-oxopropanoate, (S)-1-benzhydryl-3-hydroxy-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, 1,4-bis[[(8α,9R)-10,11-dihydro-6′-methoxy- cinchonan-9-yl]oxy]-9,10-Anthracenedione, Dihydroquinine DerivativeCyclization, Cyclization, Further Cyclizations
Domino Aldol Cyclization, 4-nitrobenzaldehyde, benzhydryl 2-cyanoacetate, benzhydryl (4R,5S)-5-(4-nitrophenyl)-4,5-dihydrooxazole-4-carboxylate, silver oxide, N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydroquinine DerivativeAldol, Aldol, Cyclization, Cyclization, Further Cyclizations
[4+2] Annulation, substituted 2,6-di-tert-butyl-4-(2-hydroxybenzylidene)cyclohexa-2,5-dien-1-one, substituted 2-cyanoacetate, 3-substituted (4R)-4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxochromane-3-carbonitrile, N-[(9R)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide, Dihydroquinine DerivativeAddition
Steglich, Aldol, benzyl 2-(((benzyloxy)carbonyl)oxy)-3-methylindoline-1-carboxylate, 4-nitrobenzaldehyde, benzyl (R)-3-((S)-(((benzyloxy)carbonyl)oxy)(4-nitrophenyl)methyl)-3-methyl-2-oxoindoline-1-carboxylate, (8α,9R)-1-[(4,4′′-dimethoxy[1,1′:3′,1′′-terphenyl]-5′-yl)methyl]-6′-hydroxy-9-(phenylmethoxy)-cinchonanium inner salt, Cupreine DerivativeAldol, Aldol, Further reactions, Steglich rearrangement
Mannich reaction, 3,5-disubstituted indolin-2-one, substituted (E)-N-tosylformimidoyl, N-((S)-substituted-((S)-3,5-disubstituted-2-oxoindolin-3-yl)methyl)-4-methylbenzenesulfonamide, (8α,9R)-9-(9-phenanthrenyloxy)-cinchonan-6′-ol, Cupreine DerivativeMannich, Mannich
Sulfa-Michael Mannich cascade, thiols, 1,3 disubstituted (E)-prop-2-en-1-one, substituted (Z)-N-tosylformimidoyl, N-((1R,2R,3S)-2-(substituted-carbonyl)-1,3-disubstituted-3-(substitutedthio)propyl)-4-methylbenzenesulfonamide, (8α,9R)-1-[(2-nitrophenyl)methyl]-9-(2-propen-1-yloxy)-6′-(4-propylphenyl)-cinchonanium bromide, Cupreine DerivativeCascade reaction, Mannich, Mannich, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition
Sulfa-Michael Henry, substituted 2-mercaptoquinoline-3-carbaldehyde, substituted (E)-nitroethene, substituted (2R,3S,4R)-2-substituted-3-nitro-3,4-dihydro-2H-thiopyrano[2,3-b]quinolin-4-ol, (8α,9R)-9-butoxy-cinchonan-6′-ol, Cupreine DerivativeCyclization, Cyclization, Further Cyclizations, Henry, Henry, Michael Addition, Sulfa-Michael, Sulfa-Michael Addition
1,6-Conjugate Addition, substituted 4-benzylidene-2,6-di-tert-butylcyclohexa-2,5-dien-1-ol, disubstituted (diazomethyl)phosphonate, substituted ((2S)-2-(3,5-di-tert-butyl-4-hydroxycyclohexa-2,5-dien-1-yl)-1-diazo-2-phenylethyl)phosphonate, 1-[[3,5-bis(1,1-dimethylethyl)-2,6-diethoxyphenyl]methyl]-9-hydroxy-6′-(2-naphthalenyl)-cinchonanium chloride, Cupreine DerivativeAddition
Bromoaminocyclization, (E)-N-(5-substituted-pent-4-en-1-yl)-4-nitrobenzenesulfonamide, 1,3-Dibromo-5,5-Dimethylhydantoin, 2-substituted (2R,3S)-3-bromo-1-((4-nitrophenyl)sulfonyl)piperidine, (8α,9R)-9-[N-(2,4-dimethoxyphenyl)carbamothioate]-6′-(2,2-dimethylpropoxy)-cinchonan-9-ol, Cupreine DerivativeBromination, Cyclization, Further Cyclizations, Intramolecular cyclization
Bromoaminocyclization, substituted 4-nitro-N-(pent-4-en-1-yl)benzenesulfonamide, N-Bromosuccinimide, 2-substituted 2-(bromomethyl)-1-((4-nitrophenyl)sulfonyl)pyrrolidine, (8α,9R)-9-[N-(2,6-diethoxyphenyl)carbamothioate]-6′-(3-methylbutoxy)-cinchonan-9-ol, Cupreine DerivativeBromination, Cyclization, Further Cyclizations, Intramolecular cyclization
