Organocatalytic Asymmetric Direct Vinylogous Michael Initiated Ring Closure Reaction of 4-Nitroisoxazole Derivatives to 3-Isopropylidene Oxindoles.
DOI Number:
10.1021/acs.joc.3c02125
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
tert-butyl 2-oxo-3-(propan-2-ylidene)indoline-1-carboxylate, 5-(chloromethyl)-3-methyl-4-nitroisoxazole
Product:
tert-butyl (1R,3S)-2,2-dimethyl-3-(3-methyl-4-nitroisoxazol-5-yl)-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-carboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylurea
Cas No:
957770-67-1
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2