Cinchona Alkaloid Squaramide-Catalyzed Asymmetric Ugi-Type Reaction of Isocyanoacetates with C,N-Cyclic Azomethine Imines: Access to Chiral Oxazole-Substituted Tetrahydroisoquinolines.
DOI Number:
10.1021/acs.joc.9b01955
Reaction Category:
RXNO ID:
RXNO_0000129
Educt:
α-aryl-substituted isocyanoacetates, C,N-cyclic azomethine imines
Product:
C1-oxazole-substituted tetrahydroisoquinolines
Catalyst:
3-[[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1565829-19-7
Associated Product from Buchler GmbH:
Dihydroquinine Base
Cas No:
522-66-7