Me2 (CH2Cl) SiCF3 Facilitated Tandem Synthesis of Oxasilacycles Featuring a Trifluoromethyl Group.

DOI Number:

10.1021/acs.orglett.2c03393
Link to literature

Reaction Category:

Cyclization | Cyclization | Fluorination | Fluoromethylation | Further Cyclizations | Trifluoromethylation

MOP ID:

MOP_0000368

Educt:

(chloromethyl)dimethyl(trifluoromethyl)silane, substituted 1-phenylbutan-1-one

Product:

substituted (4S,6R)-4-substituted-2,2,dimethyl-6-phenyl-6-(trifluoromethyl)-1,2-oxasilinane

Catalyst:

(9S)-(9′′S)-1,1′′-[1,3-phenylenebis(methylene)]bis[9-hydroxy-cinchonanium bromide (1:2)

Cas No:

479070-35-4

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5