A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert–Prakash Reagent.

DOI Number:

10.1002/ejoc.201101038

Reaction Category:

MOP ID:

MOP_0000368

Educt:

substituted 2-methylene-5-oxopyrazolidin-2-ium-1-ide, trimethyl(trifluoromethyl)silane

Product:

substituted 1-(2,2,2-trifluoroethyl)pyrazolidin-3-one

Catalyst:

1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-(9S)-Cinchonanium bromide (1:1)

Cas No:

947508-14-7

Cas No:

118-10-5