A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert–Prakash Reagent.
DOI Number:
10.1002/ejoc.201101038
Reaction Category:
MOP ID:
MOP_0000368
Educt:
substituted 2-methylene-5-oxopyrazolidin-2-ium-1-ide, trimethyl(trifluoromethyl)silane
Product:
substituted 1-(2,2,2-trifluoroethyl)pyrazolidin-3-one
Catalyst:
1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-9-hydroxy-(9S)-Cinchonanium bromide (1:1)
Cas No:
947508-14-7
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5