Alkynyl Cinchona Catalysts affect Enantioselective Trifluoromethylation for Efavirenz under Metal-Free Conditions.
DOI Number:
10.1021/acs.orglett.6b02807
Reaction Category:
MOP ID:
MOP_0000368
Educt:
1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one, trimethyl(trifluoromethyl)silane
Product:
(S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
Catalyst:
(8α,9R)-9-butoxy-10,11-didehydro-6′-methoxy- 1-[[3,3′′,5,5′′-tetrakis(trifluoromethyl) [1,1′:3′,1′′-terphenyl]-5′-yl]methyl]-Cinchonanium bromide
Cas No:
2021241-34-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0