A cation-directed enantioselective sulfur-mediated michael/mannich three-component domino reaction involving chalcones as michael acceptors.

DOI Number:

10.1021/acs.orglett.5b01833
Link to literature

Reaction Category:

Cascade reaction | Mannich | Mannich | Michael Addition | Sulfa-Michael | Sulfa-Michael Addition

RXNO ID:

RXNO_0000032

Educt:

thiols, 1,3 disubstituted (E)-prop-2-en-1-one, substituted (Z)-N-tosylformimidoyl

Product:

N-((1R,2R,3S)-2-(substituted-carbonyl)-1,3-disubstituted-3-(substituted-thio)propyl)-4-methylbenzenesulfonamide

Catalyst:

(8α,9R)-1-[(2-nitrophenyl)methyl]-9-(2-propen-1-yloxy)-6′-(4-propylphenyl)-cinchonanium bromide

Cas No:

1804927-45-4

Associated Product from Buchler GmbH:

Cupreine Base

Cas No:

524-63-0