Organocatalytic Asymmetric Strecker Reaction of Di- and Trifluoromethyl Ketoimines. Remarkable Fluorine Effect.
DOI Number:
10.1021/ol201316z
Reaction Category:
RXNO ID:
RXNO_0000207
Educt:
trifluoromethyl ketoimines, trimethylsilanecarbonitrile
Product:
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-phenylpropanenitrile
Catalyst:
N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(9S)- 10,11-dihydro-6′-methoxycinchonan-9-yl]- Thiourea
Cas No:
1229440-70-3
Associated Product from Buchler GmbH:
Dihydroquinidine Base
Cas No:
1435-55-8