Enantioselective Strecker-type reaction between azomethine imines and trimethylsilyl cyanide catalyzed by a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors.
DOI Number:
10.1039/C3RA41640B
Reaction Category:
RXNO ID:
RXNO_0000207
Educt:
azomethine imines, trimethylsilyl cyanide
Product:
(S)-2-(3-oxopyrazolidin-1-yl)-2-Arylacetonitrile
Catalyst:
N-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]-thiourea
Cas No:
1491173-70-6
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0