Organocatalytic oxa/aza-Michael–Michael cascade strategy for the construction of spiro [chroman/tetrahydroquinoline-3,3′-oxindole] scaffolds.

DOI Number:

10.1021/ol401595g
Link to literature

Reaction Category:

Aza-Michael | Michael Addition | Oxa-Michael Addition | Spirocyclization

RXNO ID:

RXNO_0000009

Educt:

substituted tert-butyl (E)-3-(2-alkoxy-2-oxoethylidene)-2-oxoindoline-1-carboxylate, substituted (E)-2-(2-nitrovinyl)phenol

Product:

spiro [chroman/tetrahydroquinoline-3,3′-oxindole] scaffolds

Catalyst:

3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0