Highly diastereo-and enantioselective synthesis of isoxazolone-spirooxindoles via squaramide-catalyzed cascade Michael/Michael addition reactions.
DOI Number:
10.1021/acs.joc.0c02150
Reaction Category:
Educt:
substituted ethyl (E)-3-((2-oxoindolin-3-yl)oxy)acrylate, substituted 4-methyleneisoxazol-5(4H)-one
Product:
isoxazolone-spirooxindoles
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0