An organocatalytic Michael-aldol cascade: formal [3+2] annulation to construct enantioenriched spirocyclic oxindole derivatives.

DOI Number:

10.1039/C2CC30931A
Link to literature

Reaction Category:

Aldol | Aldol | Cyclization | Michael Addition | Spirocyclization | Sulfa-Michael | Sulfa-Michael Addition

RXNO ID:

RXNO_0000016

Educt:

substituted ethyl (E)-2-(1-methyl-2-oxoindolin-3-ylidene)acetate, 1,4-dithiane-2,5-diol

Product:

substituted ethyl (2'S,3R,4'R)-4'-hydroxy-1-methyl-2-oxo-4',5'-dihydro-2'H-spiro[indoline-3,3'-thiophene]-2'-carboxylate

Catalyst:

3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[(9R)-cinchonan-9-ylamino]-3- cyclobutene-1,2-dione

Cas No:

1256245-82-5

Associated Product from Buchler GmbH:

Cinchonine Base

Cas No:

118-10-5