Asymmetric synthesis of tetrahydroisoquinoline-fused spirooxindoles as Ras-GTP inhibitors that inhibit colon adenocarcinoma cell proliferation and invasion.
DOI Number:
10.1039/C8CC04732D
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
N/C-substituted tert-butyl (E)-(2-oxoindolin-3-ylidene)carbamate, 2-methyl-3,5-dinitrobenzaldehyde
Product:
N/C-substituted tert-butyl (1'R,3R)-1'-hydroxy-5',7'-dinitro-2-oxo-1',4'-dihydro-2'H-spiro[indoline-3,3'-isoquinoline]-2'-carboxylate
Catalyst:
Cinchonine Base
Cas No:
118-10-5
Associated Product from Buchler GmbH:
Cinchonine Base
Cas No:
118-10-5