Enantioselective synthesis of spiro[4H-pyran-3,3′-oxindole] derivatives catalyzed by cinchona alkaloid thioureas: Significant water effects on the enantioselectivity.
DOI Number:
10.1080/00397911.2019.1651866
Reaction Category:
Educt:
isatin, malononitrile, ethyl acetoacetate
Product:
ethyl (S)-2'-amino-3'-cyano-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate
Catalyst:
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-(8α,9S)-cinchonan-9-ylthiourea
Cas No:
890044-38-9
Associated Product from Buchler GmbH:
Cinchonidine Base
Cas No:
485-71-2