A bifunctional squaramide-catalysed enantioselective vinylogous Michael addition/cyclization cascade reaction of 4-unsaturated isoxazol-5-ones and α,α-dicyanoalkenes.
DOI Number:
10.1039/D1OB01256H
Reaction Category:
Educt:
4-unsaturated isoxazol-5-ones, α,α-dicyanoalkenes
Product:
substituted (R)-6-imino-1-oxo-2-oxa-3-azaspiro[4.5]deca-3,7-diene-7-carbonitrile
Catalyst:
3-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione
Cas No:
1256245-85-8
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0