Tandem Allylic Amination/oxa-Michael Addition of Vinyl Methylene Cyclic Carbonates via Palladium-Organo Relay Catalysis.

DOI Number:

10.1021/acs.orglett.3c02014
Link to literature

Reaction Category:

Amination | Cyclization | Cyclization | Further Cyclizations | Michael Addition | Oxa-Michael Addition

MOP ID:

MOP_0000561

Educt:

N-protected 2-amino-5-(trifluoromethyl)phenol, vinyl methylene cyclic carbonates

Product:

N-protected (S)-1-(7-(trifluoromethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propan-2-one

Catalyst:

tetrakis(triphenylphosphine)palladium, 3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione

Cas No:

1256245-84-7

Associated Product from Buchler GmbH:

Quinine Base

Cas No:

130-95-0