Stereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C−H Functionalization/Oxa-Michael Addition Cascade.

DOI Number:

10.1021/jacs.1c03498

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

2,6-dichlorophenyl (E)-2-diazo-4-phenylbut-3-enoate, 3-(diethylamino)phenol,

Product:

2,6-dichlorophenyl 2-((2R,3S)-6-(diethylamino)-3-phenyl-2,3-dihydrobenzofuran-2-yl)acetate

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7