Organocatalytic enantioselective Mukaiyama–Mannich reaction of fluorinated enol silyl ethers and cyclic N-sulfonyl ketimines.

DOI Number:

10.1039/C5QO00407A
Link to literature

Reaction Category:

Further reactions | Mukaiyama-Mannich

Educt:

ethyl benzo[d]isothiazole-3-carboxylate 1,1-dioxide, ((2,2-difluoro-1-phenylvinyl)oxy)trimethylsilane

Product:

ethyl (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-2,3-dihydrobenzo[d]isothiazole-3-carboxylate 1,1-dioxide

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-Urea

Cas No:

871334-33-7

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7