Asymmetric Organocatalysis and Continuous Chemistry for an Efficient and Cost-Competitive Process to Pregabalin.

DOI Number:

10.1021/acs.oprd.1c00394

Reaction Category:

RXNO ID:

RXNO_0000009

Educt:

(E)-4-methyl-1-nitropent-1-ene, dimethyl malonate

Product:

dimethyl (S)-2-(4-methyl-1-nitropentan-2-yl)malonate

Catalyst:

3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione

Cas No:

1431159-77-1

Cas No:

56-54-2