Enantioselective michael addition of nitromethane to α, β-enones catalyzed by chiral quaternary ammonium salts. A simple synthesis of (R)-baclofen.
DOI Number:
10.1021/ol0068344
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
alpha,beta-enone, nitromethane
Product:
(R)-baclofen
Catalyst:
(9R)-1-(9-anthracenylmethyl)-10,11-dihydro-9-(phenylmethoxy)-cinchonanium bromide
Cas No:
321575-59-1
Associated Product from Buchler GmbH:
Dihydrocinchonine
Cas No:
485-65-4