Dual-function cinchona alkaloid catalysis: catalytic asymmetric tandem conjugate addition−protonation for the direct creation of nonadjacent stereocenters.
DOI Number:
10.1021/ja060312n
Reaction Category:
RXNO ID:
RXNO_0000009
Educt:
2-chloroacrylonitrile, S-methyl 2-cyanopropanethioate
Product:
S-methyl (2S,4R)-4-chloro-2,4-dicyano-2-methylbutanethioate
Catalyst:
(9S)-9-acetate-cinchonan-6′,9-diol
Cas No:
884630-36-8
Associated Product from Buchler GmbH:
Cupreidine Base
Cas No:
70877-75-7