Cinchona Alkaloid Squaramide/AgOAc Cooperatively Catalyzed Diastereo- and Enantioselective Mannich/Cyclization Cascade Reaction of Isocyanoacetates and Cyclic Trifluoromethyl Ketimines.
DOI Number:
10.1021/ol502123z
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
substituted 2-isocyanoacetic acid ester, cyclic trifluoromethyl ketimines
Product:
trifluoromethyl-substituted tetrahydroimidazo[1,5-c]quinazoline derivatives
Catalyst:
3-[[(1R,2S)-2-Hydroxy-1,2-diphenylethyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-cyclobutene-1,2-dione
Cas No:
1622403-02-4
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0