Catalytic asymmetric construction of vicinal tetrasubstituted stereocenters by the Mannich reaction of linear α-substituted monothiomalonates with Isatin N-Boc ketimines.

DOI Number:

10.1021/acs.joc.5b00302
Link to literature

Reaction Category:

Mannich | Mannich

RXNO ID:

RXNO_0000032

Educt:

isatin N-Boc ketimines, α-substituted monothiomalonates

Product:

3,3-disubstituted oxindoles

Catalyst:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7

Associated Product from Buchler GmbH:

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea

Cas No:

852913-16-7