Direct Catalytic Asymmetric Mannich Reaction with Dithiomalonates as Excellent Mannich Donors: Organocatalytic Synthesis of (R)‐Sitagliptin.
DOI Number:
10.1002/anie.201605167
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
imines, dithiomalonates
Product:
S,S-dibenzyl (S)-2-(((tert-butoxycarbonyl)amino)(phenyl)methyl)propanebis(thioate)
Catalyst:
3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4- [[(8α,9S)-6′-methoxycinchonan-9-yl]amino]- 3-Cyclobutene-1,2-dione
Cas No:
1210360-60-3
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0