Catalytic enantio-and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines.

DOI Number:

10.1039/C6CC04132A
Link to literature

Reaction Category:

Mannich | Mannich

RXNO ID:

RXNO_0000032

Educt:

(E)-P,P-diphenyl-N-(1-phenylethylidene)phosphinic amide, tert-butyl 2-cyanopropanoate

Product:

tert-butyl (4S,5R)-4,5-dimethyl-4-phenyl-4,5-dihydro-1H-imidazole-5-carboxylate

Catalyst:

N-[(8α,9S)-10,11-dihydro-6′-methoxycinchonan-9-yl]-2-(diphenylphosphino)-benzamide

Cas No:

1630973-06-6

Associated Product from Buchler GmbH:

Dihydroquinine Base

Cas No:

522-66-7