Squaramide-catalyzed asymmetric Mannich reactions of azlactones with Isatin-derived ketimines: access to α, β-diamino acid derivatives bearing vicinal quaternary stereocenters.
DOI Number:
10.1021/acs.joc.9b03000
Reaction Category:
RXNO ID:
RXNO_0000032
Educt:
azlactones, isatin-derived ketimines
Product:
substituted 4-((S)-3-amino-2-oxoindolin-3-yl)oxazol-5(4H)-one
Catalyst:
3-[[3,5-bis(trifluoromethyl)phenyl]amino]-4-[[(8α,9S)-6′-methoxycinchonan-9-yl]amino]-3-Cyclobutene-1,2-dione
Cas No:
1256245-84-7
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0