Organocatalytic asymmetric construction of tetrasubstituted carbon stereocenters bearing three heteroatoms via intramolecular cyclization of vinylidene ortho-quinone methide with imidates.
DOI Number:
10.1021/acs.orglett.2c01842
Reaction Category:
MOP ID:
MOP_0000561
Educt:
methyl (E)-N-(2-((2-hydroxynaphthalen-1-yl)ethynyl)phenyl)isobutyrimidate, N-Bromsuccinimid
Product:
1-bromopyrrolidine-2,5-dione--(8S)-14-bromo-8-isopropyl-8-methoxy-14,14a-dihydro-8H-naphtho[1',2':5,6][1,3]oxazino[3,4-a]indole
Catalyst:
N-[(8α,9S)-6′-Methoxycinchonan-9-yl]- 4-(trifluoromethyl)benzamide
Cas No:
2768033-07-2
Associated Product from Buchler GmbH:
Quinine Base
Cas No:
130-95-0